Results 151 to 160 of about 46,425 (225)

MERS-CoV remains a persistent threat amid global events

Journal of Infection and Public Health
Jaffar A. Al-Tawfiq, Sameera Al Johani, Ziad A. Memish   +2 more
doaj   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

The Systemic Inflammation Response Index (SIRI) for Stratifying Mortality Risk in Multidrug-Resistant Lower Respiratory Tract Infections Acquired in Hospital Settings. [PDF]

Can J Infect Dis Med Microbiol
Hui X, Ge X, Liu Y, Zhou J, Feng Y, Zhu H.   +5 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Practice Variations in the Management of <i>Clostridioides difficile</i> Infection: Findings From a Survey of US Physicians. [PDF]

Gastro Hep Adv
Deshpande A, Hohmann EL, Burns C, Tomeo NJ, Allegretti JR.   +4 more
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Characterizing β-lactam allergy prevalence among patients receiving infectious disease specialty care within a large US healthcare system in Washington. [PDF]

JAC Antimicrob Resist
Colas K, Ma J, Lan KF, Berzkalns A, Li L.   +4 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

The emergence of Oropouche virus in Cuba – A wake-up call for global health

Journal of Infection and Public Health
Jaffar A. Al-Tawfiq, Alfonso J. Rodriguez-Morales, Sameera Al Johani   +2 more
doaj   +1 more source

Pandemic to endemic: a longitudinal multinational study on COVID-19's effects on graduate medical education. [PDF]

BMC Med Educ
Msheik-El Khoury F, Oon JEL, Lewis L, Ibrahim H, Archuleta S.   +4 more
europepmc   +1 more source