Results 181 to 190 of about 47,216 (216)

How AI will redefine care delivery: the rise of the generalist-specialist. [PDF]

Health Aff Sch
Kocher B, Nolan-Mangini S, Wachter RM.
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Mpox outbreak in South Africa: A wake-up call for strengthening preparedness and response

New Microbes and New Infections
Jaffar A. Al-Tawfiq, Qiuwei Pan, Patricia Schlagenhauf   +2 more
doaj   +1 more source

Exploring barriers and facilitators for non-communicable disease care for persons living with HIV in Peru through a socioecological framework: HIV physician and coordinator perspectives. [PDF]

PLOS Glob Public Health
Slotkin R, Granda D, Hernandez JM, Cabrera D, Benites CM, Garcia PJ, Hsieh E.   +6 more
europepmc   +1 more source

FADS2‐STING Signaling in Sertoli Cells Orchestrates Collagen Deposition and Germ Cell Necroptosis in Idiopathic Non‐Obstructive Azoospermia

Advanced Science, EarlyView.
In Sertoli cells of iNOA testes, downregulation of FADS2 activates STING, promoting collagen deposition and peritubular fibrosis while increasing germ‐cell susceptibility to necroptosis. Supplementation with FADS2‐derived PUFAs (GLA and DHA) inhibits STING, alleviates collagen accumulation, and facilitates the recovery of spermatogenesis.
Jiajing Lin, Hongfei Ke, Xiaomin Li, Man Wu, Zhengyan Wu, Zhiying Huang, Feixue Han, Dejian Pang, Shuyan Chen, Tianwen Peng, Yu Lan, Xin Fu, Yingying Zhang, Hyeon Jeong Lee, Zhicong Chen, Geng An   +15 more
wiley   +1 more source

Physician Awareness of Hereditary Angioedema: A Cross-Sectional Survey with Emphasis on Medication-Related Triggers. [PDF]

J Clin Med
Sevimli N, Durmaz MSB, Altıner S.
europepmc   +1 more source

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

Rocky Mountain spotted fever presenting with complete heart block: A rare manifestation of Rickettsial disease. [PDF]

HeartRhythm Case Rep
Samuel AR, Malavade S, Arunthamakun J.
europepmc   +1 more source

Practice Variations in the Management of <i>Clostridioides difficile</i> Infection: Findings From a Survey of US Physicians. [PDF]

Gastro Hep Adv
Deshpande A, Hohmann EL, Burns C, Tomeo NJ, Allegretti JR.   +4 more
europepmc   +1 more source