Results 41 to 50 of about 46,124 (173)

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Practical tips for bedside teaching of infectious diseases practice to junior doctors

MedEdPublish, 2017
Infectious diseases, being a cognitive specialty, is commonly perceived to be difficult to teach at the bedside. Most junior doctors have had variable amounts of exposure to infectious diseases as medical students, primarily in the form of lectures as ...
Sharavan Sadasiv Mucheli, Sophia Archuleta   +1 more
doaj  

Clinical Presentation and Outcome of Hospitalized Patients With COVID-19 in the First and Second Waves in Saudi Arabia

International Journal of Infectious Diseases, 2022
Introduction: The world had witnessed the occurrence of multiple waves of the SARS-CoV-2. Data comparing the clinical characteristics and outcomes of hospitalized patients in Saudi Arabia during the first and second waves are lacking. This study compares
Salma AlBahrani, Nayef AlAhmadi, Safa Hamdan, Noura Elsheikh, Assim Osman, Sharifah Almuthen, Ghadeer N Almajed, Arwa H Alkhuraim, Arulanantham Zechariah Jebakumar, Jaffar A. Al-Tawfiq   +9 more
doaj  

Improving Tuberculosis (TB) Prediction using Synthetically Generated Computed Tomography (CT) Images [PDF]

arXiv, 2021
The evaluation of infectious disease processes on radiologic images is an important and challenging task in medical image analysis. Pulmonary infections can often be best imaged and evaluated through computed tomography (CT) scans, which are often not available in low-resource environments and difficult to obtain for critically ill patients.
arxiv  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Comparative point prevalence survey of antimicrobial consumption between a hospital in Northern Ireland and a hospital in Jordan

BMC Health Services Research, 2018
Background To assess antimicrobial prescribing in a Northern Ireland hospital (Antrim Area Hospital (AAH)) and compare them with those of a hospital in Jordan (Specialty Hospital).
Feras Darwish Elhajji, Ghaith M. Al-Taani, Lana Anani, Sahar Al-Masri, Haneen Abdalaziz, Su’ad H. Qabba’h, Abdel Qader Al Bawab, Michael Scott, David Farren, Fiona Gilmore, Ann Versporten, Herman Goossens, Mamoon A. Aldeyab   +12 more
doaj   +1 more source

Precision Medicine: Changing the way we think about healthcare

Clinics, 2018
Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and non-contagious diseases, with a direct impact on the cost of public health and individual health care.
Gustavo Rosa Gameiro, Viktor Sinkunas, Gabriel Romero Liguori, José Otavio Costa Auler-Júnior   +3 more
doaj   +1 more source

Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia

International Journal of Infectious Diseases, 2021
Introduction: The Kingdom of Saudi Arabia was one of the first countries to implement a COVID-19 vaccination program. This study estimated the safety and reactogenicity of the ChAdOx1-S vaccine after the first dose administered to adults.
Salma Al Bahrani, Ali Albarrak, Othman Ali Alghamdi, Mesfer Abdullah Alghamdi, Fatimah H. Hakami, Asmaa K. Al Abaadi, Sausan A. Alkhrashi, Mansour Y. Alghamdi, Meshael M. Almershad, Mansour Moklif Alenazi, Mohamed Hany El Gezery, Arulanantham Zechariah Jebakumar, Jaffar A. Al-Tawfiq   +12 more
doaj  

Capturing what matters: Patient‐reported LGI1‐ANTibody encephalitis outcome RatiNg scale (LANTERN)

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Background LGI1‐antibody encephalitis (LGI1‐Ab‐E) is a common form of autoimmune encephalitis where most patients demonstrate ‘good’ clinician‐rated outcomes. However, more targeted questionnaires reveal numerous debilitating symptoms for many years.
Mark J Kelly, Barbara Wagner, Bryan Ceronie, Christine Strippel, Ann Yee Lin, Adam Handel, John Soltys, Sophie Binks, Philip A Powell, Sarosh R Irani   +9 more
wiley   +1 more source

ECG for high-throughput screening of multiple diseases: Proof-of-concept using multi-diagnosis deep learning from population-based datasets [PDF]

arXiv, 2022
Electrocardiogram (ECG) abnormalities are linked to cardiovascular diseases, but may also occur in other non-cardiovascular conditions such as mental, neurological, metabolic and infectious conditions. However, most of the recent success of deep learning (DL) based diagnostic predictions in selected patient cohorts have been limited to a small set of ...
arxiv