Results 61 to 70 of about 110,474 (266)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Witnessing history: a personal view of half a century in public health [PDF]

, 2018
Former Chief Medical Officer Sir Kenneth Calman recently celebrated 50 years in medicine. It was a period which saw the evolution of the public health agenda from communicable diseases to diseases of lifestyle, the change from a hospital-orientated ...
Bergman, B.P., Calman, K.C., Chandler, A.S., Laing, F.   +3 more
core   +2 more sources

Practice transformations to optimize the delivery of HIV primary care in community healthcare settings in the United States: A program implementation study. [PDF]

, 2020
BackgroundThe United States HIV care workforce is shrinking, which could complicate service delivery to people living with HIV (PLWH). In this study, we examined the impact of practice transformations, defined as efficiencies in structures and delivery ...
Botta, Emma Wilde, Bromer, Steven, Fuller, Shannon M, Gaffney, Stuart, Guzé, Mary A, Heath, Corliss D, Kirby, Valerie B, Koester, Kimberly A, Moran, Mary E, Shade, Starley B, Steward, Wayne T   +10 more
core   +2 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

P-899. Strong Hearts Program: Results of a Novel Primary-Care Based Chagas Disease Care Program in East Boston, MA, 2017-2023

Open Forum Infectious Diseases
Background Chagas disease is a neglected parasitic infection that affects ∼300,000 people in the US, with a prevalence of ∼49 per 100,000 in Massachusetts, USA. Untreated Chagas disease leads to irreversible cardiac morbidity and death in 20-30% of cases,
Javier J Huerta, Ashley Maldonado, Carly Milliren, Jillian Hertig, Katherine Collins, Jim Gomes, A. Salazar, Daniel Bourque, Natasha S Hochberg, David H. Hamer, Leonard L Levin, Jaime Gallegos Salazar, Elizabeth D Barnett, Juan Huanuco, Jennifer Manne-Goehler, Julia R. Köhler   +15 more
semanticscholar   +1 more source

Dynamic Patterns and Predominance of Respiratory Pathogens Post-COVID-19: Insights from a Two-Year Analysis

Journal of Epidemiology and Global Health
Introduction Respiratory tract infections (RTIs) stand out as the most frequent causes leading to visits to the emergency department and hospitalizations.
Salma AlBahrani, Samira Jamaan AlZahrani, Thekra N. Al-Maqati, Atheer Almehbash, Anfal Alshammari, Refan Bujlai, Sarah Ba Taweel, Fares Almasabi, Abdullah AlAmari, Jaffar A. Al-Tawfiq   +9 more
doaj   +1 more source

A horse or a zebra? Unusual manifestations of common cutaneous infections in primary immunodeficiency pediatric patients

Frontiers in Pediatrics, 2023
BackgroundPatients with primary immunodeficiency disorders (PIDs) often suffer from recurrent infections because of their inappropriate immune response to both common and less common pathogens.
Ayelet Ollech, Ayelet Ollech, Amos J Simon, Amos J Simon, Amos J Simon, Atar Lev, Tali Stauber, Tali Stauber, Gilad Sherman, Gilad Sherman, Michal Solomon, Michal Solomon, Aviv Barzilai, Aviv Barzilai, Raz Somech, Raz Somech, Raz Somech, Shoshana Greenberger, Shoshana Greenberger   +18 more
doaj   +1 more source