Results 71 to 80 of about 46,124 (173)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

Advanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang, Mara Artibani, Yongcheng Jin, Aneesh Aggarwal, Yujia Zhang, Sandra Muñoz‐Galvan, Ellina Mikhailova, Lena Rai, Nobina Mukherjee, Ravinash Krishna Kumar, Ashwag Albukhari, Shaohua Ma, Linna Zhou, Ahmed Ashour Ahmed, Hagan Bayley   +14 more
wiley   +1 more source

A Spectrum Evaluation Benchmark for Medical Multi-Modal Large Language Models [PDF]

arXiv
The significant breakthroughs of Medical Multi-Modal Large Language Models (Med-MLLMs) renovate modern healthcare with robust information synthesis and medical decision support. However, these models are often evaluated on benchmarks that are unsuitable for the Med-MLLMs due to the complexity of real-world diagnostics across diverse specialties.
arxiv  

Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram‐Positive Bacteria

Advanced Healthcare Materials, EarlyView.
Efflux‐mediated resistance compromises antibiotic efficacy, yet rapid detection remains elusive. This study presents a novel phenazinium‐based diagnostic molecule for quantifying bacterial efflux levels in Gram‐positive pathogens. The optimized compound enables precise, real‐time efflux assessment using fluorescence and colorimetric techniques ...
Mrunal Patil, Tatiana Munteanu, Gaël Brasseur, Carolina Ferreira, Sofia Santos Costa, Isabel Couto, Mohd Athar, Elisa Asunis, Attilio Vittorio Vargiu, Miguel Viveiros, Carole DiGiorgio, Frédéric Brunel, Jean‐Manuel Raimundo, Michel Camplo, Olivier Siri, Jean‐Michel Bolla   +15 more
wiley   +1 more source

Physician perspectives on the management of viral hepatitis and hepatocellular carcinoma in Myanmar.

PLoS ONE, 2017
BackgroundIn Myanmar, over five million people are infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Hepatitis has been a recent focus with the development of a National Strategic Plan on Hepatitis and plans to subsidize HCV treatment ...
Yoona A Kim, Sam Trinh, Si Thura, Khin Pyone Kyi, Thomas Lee, Stan Sze, Adam Richards, Andrew Aronsohn, Grace L H Wong, Yasuhito Tanaka, Geoffrey Dusheiko, Mindie H Nguyen   +11 more
doaj   +1 more source

Co‐Delivery of Multiple Toll‐Like Receptor Agonists and Avian Influenza Hemagglutinin on Protein Nanoparticles Enhances Vaccine Immunogenicity and Efficacy

Advanced Healthcare Materials, EarlyView.
This research highlights a novel application of protein nanoparticles to effectively modulate the strength, breadth, and bias of an immune response against influenza virus. Nanoparticles precisely co‐delivering antigen (H5) and multiple adjuvants (CpG and FliCc) present a way to improve and direct prophylactic immune responses which can be applicable ...
Aaron Ramirez, Jenny E. Hernandez‐Davies, Aarti Jain, Lu Wang, Erwin Strahsburger, D. Huw Davies, Szu‐Wen Wang   +6 more
wiley   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Profile of renal diseases in North-East Indian children

Saudi Journal of Kidney Diseases and Transplantation, 2019
The pattern of kidney diseases varies in different places due to differences in genetic status, socioeconomic status, access to health care, and presence of background infection.
Rimjhim Sonowal
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, EarlyView.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source