Results 111 to 120 of about 2,285,862 (398)

Development of Guidelines for Refugee Screening at CMMC Family Medicine Residency, Lewiston, Maine [PDF]

, 2016
Lewiston Maine has the second highest number of refugees in the state of Maine, with 191 total intakes in 2015. Refugee populations face unique health concerns, and providing care for refugees requires education and development of a specialized skill ...
Hayes, Catherine
core   +1 more source

AIDS-defining illnesses at initial diagnosis of HIV in a large Guatemalan cohort [PDF]

, 2017
BackgroundAnecdotal evidence suggests that a high proportion of patients diagnosed with HIV in Guatemala present with AIDS. There remain limited data on the epidemiology of AIDS-defining illnesses (ADIs) in Central America.MethodsWe conducted a ...
Cordon, Andrea Alonzo, Melendez, Johanna, Powderly, William G, Reinhardt, Samuel W, Ross, Ian, Spec, Andrej, Villatoro, Carlos Mejia   +6 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

Nature Communications
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of the urinary tract. While multi-omic
Mark G. Young, Timothy J. Straub, Colin J. Worby, Hayden C. Metsky, Andreas Gnirke, Ryan A. Bronson, Lucas R. van Dijk, Christopher A. Desjardins, Christian Matranga, James Qu, Jesús Bazan Villicana, Philippe Azimzadeh, Andrew Kau, Karen W. Dodson, Henry L. Schreiber, Abigail L. Manson, Scott J. Hultgren, Ashlee M. Earl   +17 more
doaj   +1 more source

Rates and Causes of Death in Chiradzulu District, Malawi, 2008: A Key Informant Study [PDF]

, 2010
In September 2008, we measured all-cause mortality in Chiradzulu District, Malawi (population 291 000) over a 60-day retrospective period, using capture-recapture analysis of three lists of deaths provided by (i) key community informants, (ii) graveyard ...
Adjuik, Baiden, Doctor, Fienberg, Hosegood, International Working Group for Disease Monitoring and Forecasting, Jahn, Mathers, Roberts, Setel, World Health Organization   +10 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient

The Egyptian Journal of Internal Medicine
Background Immune reconstitution inflammatory syndrome (IRIS) is a complex phenomenon commonly diagnosed with human immunodeficiency virus (HIV). However, rarely, IRIS can develop with other diseases outside of HIV.
Hussain Hussain, Aya Fadel, Ekaterina Casmartino, John Sullivan, Amanda Fernandes, Samantha Garcia, Efrain Garcia   +6 more
doaj   +1 more source

Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology

, 2021
Maicon Falavigna, Verônica Colpani, Cinara Stein, Luciano César Pontes Azevedo, Ângela Maria Bagattini, Gabriela Vilela de Brito, José Miguel Chatkin, Sérgio Cimerman, Mírian de Freitas Dal Ben Corradi, Clóvis Arns da Cunha, Flávia Cordeiro Medeiros, Haliton Alves de Oliveira, Leandro Genehr Fritscher, Marcelo Basso Gazzana, Débora Dalmas Gräf, Lays Pires Marra, Jéssica Yumi Matuoka, Michelle Silva Nunes, Daniela Vianna Pachito, Cassia Garcia Moraes, Patrícia do Carmo Silva Parreira, Rachel Riera, Amilton Silva Júnior, Bruno de Melo Tavares, Alexandre Prehn Zavascki, Régis Goulart Rosa, Felipe Dal‐Pizzol   +26 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Impact of Frailty on Major Adverse Cardiovascular Events in Chronic Obstructive Pulmonary Disease

International Journal of COPD
Kazuki Hamada,1 Keiji Oishi,1 Tasuku Yamamoto,1 Yoriyuki Murata,1 Maki Asami-Noyama,1 Nobutaka Edakuni,1 Tsunahiko Hirano,1 Takeshi Abe,2,3 Masahiko Nakatsui,2,3 Yoshiyuki Asai,2– 4 Kazuto Matsunaga1 1Department of Respiratory Medicine and Infectious ...
Hamada K, Oishi K, Yamamoto T, Murata Y, Asami-Noyama M, Edakuni N, Hirano T, Abe T, Nakatsui M, Asai Y, Matsunaga K   +10 more
doaj