Results 61 to 70 of about 771,612 (309)

Kampo Medicines for Infectious Diseases

, 2017
Numerous Kampo medicines and Oriental herbs have been used for the treatment of infectious diseases for several reasons, such as genetic background, economical reasons, fewer adverse effects, and so on. This chapter describes Kampo medicines and related Oriental herbs that are effective or promising in the treatment of infectious diseases at the ...
openaire   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

Nature Communications
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of the urinary tract. While multi-omic
Mark G. Young, Timothy J. Straub, Colin J. Worby, Hayden C. Metsky, Andreas Gnirke, Ryan A. Bronson, Lucas R. van Dijk, Christopher A. Desjardins, Christian Matranga, James Qu, Jesús Bazan Villicana, Philippe Azimzadeh, Andrew Kau, Karen W. Dodson, Henry L. Schreiber, Abigail L. Manson, Scott J. Hultgren, Ashlee M. Earl   +17 more
doaj   +1 more source

Mycobacterium tuberculosis Bacteremia in HIV-negative Patients

Journal of the Formosan Medical Association, 2007
Limited information exists about the epidemiologic characteristics of HIV-negative patients with Mycobacterium tuberculosis bacteremia (MTB). Methods: We retrospectively surveyed tuberculosis (TB) cases reported at National Taiwan University Hospital ...
Yu-Shin Chiu, Jann-Tay Wang, Shan-Chwen Chang, Jih-Luh Tang, Shih-Chi Ku, Chien-Ching Hung, Po-Ren Hsueh, Yee-Chun Chen   +7 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Ruxolitinib plus standard of care in severe hospitalized adults with severe fever with thrombocytopenia syndrome (SFTS): an exploratory, single-arm trial

BMC Medicine
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, and its morbidity and mortality are increasing. At present, there is no specific therapy available.
Sai Wen, Nannan Xu, Lianhui Zhao, Lulu Yang, Hui Yang, Caiyun Chang, Shanshan Wang, Chunmei Qu, Li Song, Wenlu Zou, Yishan He, Gang Wang   +11 more
doaj   +1 more source

The effect of travel restrictions on the geographical spread of COVID-19 between large cities in China: a modelling study

BMC Medicine, 2020
Background To contain the spread of COVID-19, a cordon sanitaire was put in place in Wuhan prior to the Lunar New Year, on 23 January 2020. We assess the efficacy of the cordon sanitaire to delay the introduction and onset of local transmission of COVID ...
Billy J. Quilty, Charlie Diamond, Yang Liu, Hamish Gibbs, Timothy W. Russell, Christopher I. Jarvis, Kiesha Prem, Carl A. B. Pearson, Samuel Clifford, Stefan Flasche, CMMID COVID-19 working group, Petra Klepac, Rosalind M. Eggo, Mark Jit   +13 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

COVID-19 length of hospital stay: a systematic review and data synthesis

BMC Medicine, 2020
Background The COVID-19 pandemic has placed an unprecedented strain on health systems, with rapidly increasing demand for healthcare in hospitals and intensive care units (ICUs) worldwide.
Eleanor M. Rees, Emily S. Nightingale, Yalda Jafari, Naomi R. Waterlow, Samuel Clifford, Carl A. B. Pearson, CMMID Working Group, Thibaut Jombart, Simon R. Procter, Gwenan M. Knight   +9 more
doaj   +1 more source

Infectious Diseases in Critical Care Medicine [PDF]

Medical Journal Armed Forces India, 2003
Few books on the subject of Critical Care Medicine are as interestingly written as this one. The book deals with practical microbiological problems that concern the Intensive Care Units; the entire narration is lucid with easy to comprehend tables, flow diagrams, labelled diagrams and photographs.
openaire   +2 more sources