Results 71 to 80 of about 746,556 (263)

Infectious Diseases in Critical Care Medicine [PDF]

Medical Journal Armed Forces India, 2003
Few books on the subject of Critical Care Medicine are as interestingly written as this one. The book deals with practical microbiological problems that concern the Intensive Care Units; the entire narration is lucid with easy to comprehend tables, flow diagrams, labelled diagrams and photographs.
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient

The Egyptian Journal of Internal Medicine
Background Immune reconstitution inflammatory syndrome (IRIS) is a complex phenomenon commonly diagnosed with human immunodeficiency virus (HIV). However, rarely, IRIS can develop with other diseases outside of HIV.
Hussain Hussain, Aya Fadel, Ekaterina Casmartino, John Sullivan, Amanda Fernandes, Samantha Garcia, Efrain Garcia   +6 more
doaj   +1 more source

Mycobacterium tuberculosis Bacteremia in HIV-negative Patients

Journal of the Formosan Medical Association, 2007
Limited information exists about the epidemiologic characteristics of HIV-negative patients with Mycobacterium tuberculosis bacteremia (MTB). Methods: We retrospectively surveyed tuberculosis (TB) cases reported at National Taiwan University Hospital ...
Yu-Shin Chiu, Jann-Tay Wang, Shan-Chwen Chang, Jih-Luh Tang, Shih-Chi Ku, Chien-Ching Hung, Po-Ren Hsueh, Yee-Chun Chen   +7 more
doaj   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

“It’s easier to take a pill than fix a problem:” qualitative analysis of barriers and facilitators to antimicrobial stewardship program implementation in carceral settings

BMC Global and Public Health
Background Widespread antibiotic prescribing contributes to globally emerging antimicrobial resistance (AMR). Despite stewardship recommendations by the Infectious Diseases Society of America, there is a lack of literature identifying barriers and ...
Rebecca A. Tenner, Emily D. Grussing, David Manning, Yvane Ngassa, Jacob J. van den Berg, Gabriela Andujar Vazquez, Shira Doron, Maureen Campion, Alysse G. Wurcel   +8 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

More medicines for neglected and emerging infectious diseases

Bulletin of the World Health Organization, 2007
Countries in the Organization for Economic Cooperation and Development (OECD) account for about 80% of gross expenditure in research and development globally,1 but their collective health research output has not led to new medicines for many of the infectious diseases that afflict developing countries; human african trypanosomiasis, leishmaniasis ...
openaire   +4 more sources