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Microglia, brain-resident innate immune cells, have been extensively studied in neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 (COVID-19) pandemic highlighted how peripheral infection and inflammation can be detrimental to the neuroimmune milieu and initiate microgliosis driven by peripheral inflammation.
Herman, Li +2 more
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Herman, Li +2 more
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Immunosenescence and infectious diseases
Microbes and Infection, 2001Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines.
GINALDI, Lia +4 more
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The Mathematics of Infectious Diseases
SIAM Review, 2000Summary: Many models for the spread of infectious diseases in populations have been analyzed mathematically and applied to specific diseases. Threshold theorems involving the basic reproduction number \(R_{0}\), the contact number \(\sigma\), and the replacement number \(R\) are reviewed for the classic SIR epidemic and endemic models.
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mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Nature Reviews Drug Discovery, 2021Namit Chaudhary +2 more
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Home Healthcare Nurse: The Journal for the Home Care and Hospice Professional, 2002
Carol O, Long +2 more
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Carol O, Long +2 more
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Evaluation of diagnostic tests for infectious diseases: general principles
Nature Reviews Microbiology, 2006Patrick M M Bossuyt +2 more
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