Results 61 to 70 of about 3,979,167 (303)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Nihon Naika Gakkai Zasshi, 1997 レジオネラは土壌細菌で世界中に分布しているが,近代の文化的生活における人工環境の至る所で増殖し,近年新たな展開を見せている.特に,人工環境水においては共存するアメーバを媒体として大量に増殖し,ありとあらゆる環境水からレジオネラ感染の危険性が高まっている.人工環境水の消毒の問題は人体への影響を考慮する必要があり,困難をきわめている状態である.わが国にはビル管理基準としての冷却塔におけるレジオネラ症防止指針が作成されているが,米国のCDCのような院内感染防止指針やその他の環境水に対する水の管理基準の策定はこれからである.診断法はPCR法や尿中抗原検出などかなりの進歩が見られているので,疑わしい症例では積極的にしかるべき施設へ依頼してでも確定診断を得る努力をする必要がある.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2010 Conclusions: Increased serum ferritin levels may suggest a significant role of hemophagocytosis in the pathogenesis of CCHF and may be a useful marker for diagnosis, disease activity, and prognosis. (C) 2009 International Society for Infectious Diseases.
Erkorkmaz, Ünal
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Nihon Naika Gakkai Zasshi, 1997 ハンタウイルスとは,ブニヤウイルス科ハンタウイルス属に含まれる一群のウイルスを指す総称である.その名は1973年李たちによって分離されたハンターンウイルスに由来する.ヒトに腎症候性出血熱(HFRS)やハンタウイルス肺症候群(HPS)など劇症の感染症をおこすウイルスが含まれる.ハンタウイルスの自然宿主は齧歯類であり,感染個体由来の乾燥した排泄物のエアゾールを介してヒトにも感染する.
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Infectious diseases and autoimmunity
Journal of Infection in Developing Countries, 2011 Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Lucia Gemma Delogu +3 more
doaj +1 more source