Results 41 to 50 of about 25,638 (157)

Infektsioosne mononukleoos [PDF]

, 2017
Infektsioosne mononukleoos (IM) on kliiniline sündroom, mille tekitajaks 90%-l juhtudest on gammaherpesviiruste perekonda kuuluv Epsteini-Barri viirus (EBV).
Tamm, Eda
core   +2 more sources

Animal models of human herpesvirus infection

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 615-628, April 2025.
Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Ziqing Jia, Dong Zhang, Lin Zhu, Jing Xue   +3 more
wiley   +1 more source

Pediatric epstein-barr virus carriers with or without tonsillar enlargement may substantially contribute to spreading of the virus [PDF]

, 2010
BACKGROUND: Human-to-human transmission of the persistent infection establishing Epstein-Barr virus (EBV) occurs via saliva. Tonsils act as important portal of entry and exit of EBV.
Berger, C, Dorner, M, Fröhlich, F Z, Gysin, C, Hug, M, Nadal, D, Neuhaus, D   +6 more
core   +1 more source

Leaky Artemis Deficiency and EBV‐Related Lymphoproliferative Disease: A Novel Case and Review of the Literature

eJHaem, Volume 6, Issue 2, April 2025.
ABSTRACT Introduction Artemis (DCLRE1C) deficiency causes radiosensitive severe combined immunodeficiency (SCID), although hypomorphic cases can manifest later‐onset immunodeficiency, autoimmunity, or lymphoproliferation. We report a 45‐year‐old man with humoral immunodeficiency, opportunistic infections, and recurrent EBV‐positive diffuse large B‐cell
Lucie Roussel, Stephane Bernier, Gertruda Evaristo, Anna Perez, Sanabelle Zaabat, Romina Pace, Yichun Sun, Isabelle Angers, John Storring, Donald C. Vinh   +9 more
wiley   +1 more source

CMV proctitis mimicking a rectal tumor

ANZ Journal of Surgery, EarlyView.
Wei Ming Ong, Perry Lindsay, Suat Chin Ng, David Machet, Vinna An   +4 more
wiley   +1 more source

Discovery of Novel Pyrido[2,3‐b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
We designed and synthesized a small library of novel non‐nucleoside, polymerase inhibitors of herpesviruses with a pyrido[2,3‐b]pyrazines core. Compound 27, a representative of the library, were identified with reduced hERG inhibition, and broad spectrum antiherpetic activity.
Bing Bai, Appan Srinivas Kandadai, Mostofa Hena, Alexandr Belovodskiy, John Shen, Michael Houghton, James A. Nieman   +6 more
wiley   +1 more source

Structural Insights into Broad‐Range Polyphosphate Kinase 2‐II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis

ChemBioChem, Volume 26, Issue 5, March 3, 2025.
This study reports the first substrate‐bound structures of polyphosphate kinase 2‐II (PPK2‐II) enzymes, offering insights into nucleoside diphosphate (NDP) synthesis. BcPPK2 (Bacillus cereus) and LfPPK2 (Lysinibacillus fusiformis) show a broad substrate range, and reach conversion rates of 85 % for the selective pyrimidine NDP synthesis.
Marco Kuge, Michael Keppler, Florian Friedrich, Raspudin Saleem‐Batcha, Juliana Winter, Isabel Prucker, Philipp Germer, Stefan Gerhardt, Oliver Einsle, Manfred Jung, Henning J. Jessen, Jennifer N. Andexer   +11 more
wiley   +1 more source

Applications of Artificial Intelligence in Vasculitides: A Systematic Review

ACR Open Rheumatology, Volume 7, Issue 3, March 2025.
Objective Vasculitides are rare inflammatory disorders that sometimes can be difficult to diagnose due to their diverse presentations. This review examines the use of artificial intelligence (AI) to improve diagnosis and outcome prediction in vasculitis.
Mahmud Omar, Reem Agbareia, Mohammad E. Naffaa, Abdulla Watad, Benjamin S. Glicksberg, Girish N. Nadkarni, Eyal Klang   +6 more
wiley   +1 more source

Rapid turnover of T cells in acute infectious mononucleosis.

, 2003
During acute infectious mononucleosis (AIM), large clones of Epstein-Barr virus-specific T lymphocytes are produced. To investigate the dynamics of clonal expansion, we measured cell proliferation during AIM using deuterated glucose to label DNA of ...
Asquith, Becca, Beverley, Peter C, Ghattas, Hala, Griffin, George E, Irvine, Andrew J, Macallan, Derek C, Tough, David F, Wallace, Diana L, Worth, Andrew, Zhang, Yan   +9 more
core   +1 more source

Ulcerative Lesion of the Ileocecal Region in a Patient With Immunodeficiency

Journal of Gastroenterology and Hepatology, Volume 40, Issue 6, Page 1345-1347, June 2025.
Naohiko Kinoshita, Kazuki Kakimoto, Emiri Kaji, Noboru Mizuta, Keijiro Numa, Kei Nakazawa, Ryoji Koshiba, Yuki Hirata, Takako Miyazaki, Shiro Nakamura, Hiroki Nishikawa   +10 more
wiley   +1 more source