Results 51 to 60 of about 52,025 (265)

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

Interdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan, Adnan Shakoor, Sadia Kanwal   +2 more
wiley   +1 more source

Comparative Evaluation of Cases with Community-Acquired Infective Endocarditis and Health Care-Associated Infective Endocarditis

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: The present study aimed to comparatively evaluate the cases with health care-associated infective endocarditis and the cases with community-acquired infective endocarditis. Material and Methods: Of the cases followed for infective endocarditis (
Ebru Kursun, Tuba Turunc, Yusuf Ziya Demiroglu, Turhan Togan, Goknur Tekin, Hande Arslan   +5 more
doaj  

Superantigens Are Critical for Staphylococcus aureus Infective Endocarditis, Sepsis, and Acute Kidney Injury

mBio, 2013
Infective endocarditis and kidney infections are serious complications of Staphylococcus aureus sepsis. We investigated the role of superantigens (SAgs) in the development of lethal sepsis, infective endocarditis, and kidney infections.
Wilmara Salgado-Pabón, Laura Breshears, Adam R. Spaulding, Joseph A. Merriman, Christopher S. Stach, Alexander R. Horswill, Marnie L. Peterson, Patrick M. Schlievert   +7 more
doaj   +1 more source

Infective Endocarditis - Diagnosis, Treatment and Specific Situations Management – Current Knowledge, Review of the Literature

Quality in Sport
Introduction             Infective endocarditis (IE) is a severe condition of endocardium, which can manifest through a wide spectrum of unspecific symptoms related to various organ systems.
Magdalena Balwierz, Agnieszka Kosińska, Wiktoria Belcarz   +2 more
doaj   +1 more source

Staphylococcus lugdunensis Endocarditis in a 35-Year-Old Woman in Her 24th Week of Pregnancy

Case Reports in Obstetrics and Gynecology, 2016
Background. Infective endocarditis is associated with considerable morbidity and mortality. Guidelines addressing prophylaxis and management of infective endocarditis do not extensively deal with concomitant pregnancy, and case reports on infective ...
Mounir Khafaga, Karl-Patrik Kresoja, Berndt Urlesberger, Igor Knez, Philipp Klaritsch, David Benjamin Lumenta, Robert Krause, Dirk von Lewinski   +7 more
doaj   +1 more source

Gender, Age, and Regional Disparities in the Incidence and Mortality Trends of Infective Endocarditis in the United States Between 1990 and 2019 [PDF]

, 2023
Sofia K. Mettler, Housam Alhariri, Unoma Okoli, Nipith Charoenngam, Ramon H. Guillen, Aunchalee Jaroenlapnopparat, Binu Philips, Irmgard Behlau, Robert C. Colgrove   +8 more
openalex   +1 more source

Reduced prevalence of periodontitis in antidepressant users: Findings from a large‐scale US sample

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis and major depression disorder have been shown to have a bidirectional association. However, the impact of antidepressants, the primary pharmacological treatment for depression, on periodontal health remains unclear.
María Martínez, David Fraguas, Elena Figuero, Francesco D´Aiuto   +3 more
wiley   +1 more source

Safety of Baricitinib for the Treatment of Atopic Dermatitis in Adults Over a Median of 1.6 and up to 4.6 Years Treatment: Final Integrated Analysis of Eight Clinical Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Baricitinib is a selective Janus kinase (JAK)1/JAK2 inhibitor approved in more than 70 countries for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults, and in over 30 countries for adolescents and children from age 2 years with moderate‐to‐severe AD, who are candidates for systemic therapy.
Antonio Costanzo, Antonio Torrelo, Eric L. Simpson, Marjolein De Bruin‐Weller, Diamant Thaçi, Norito Katoh, Silvia Sabatino, Andrew Buchanan, Kasia Morawska, Samuel Ogwu, Karen Denning, Jonathan I. Silverberg   +11 more
wiley   +1 more source

A case of yogurt central line‐associated bloodstream infection in a child with intestinal failure

Nutrition in Clinical Practice, EarlyView.
Abstract Central line‐associated bloodstream infections (CLABSI) are a significant cause of morbidity in children with intestinal failure (IF). Probiotic therapy is discouraged in patients with IF because of the increased risk of bacteremia with the probiotic organism.
Nasiha Rahim, Emily Keller, Ellen Wagner, Andrea Berkemeyer, Timothy Johnson, Daniel Johnson, Timothy Sentongo   +6 more
wiley   +1 more source

Acquired ventricular septal defect secondary to aortic valve endocarditis

Journal of Cardiothoracic Surgery
Infective endocarditis remains a deadly disease with a significant mortality rate. While ventricular septal defects (VSDs) have been linked to an increased risk of infective endocarditis, cases of acquired VSDs resulting from infective endocarditis are ...
Courtney M. Hanson, Maria T. Tibesar, Timothy L. Pansegrau   +2 more
doaj   +1 more source