Results 81 to 90 of about 1,785,909 (201)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Adhesion of Newly Developed Composite Resin Splinting Materials to Enamel: Effect of Enamel Surface Treatment

Dental Traumatology, EarlyView.
ABSTRACT Background/Aim To evaluate the shear bond strength (SBS) of newly developed composite resin materials intended for dental splinting to enamel and to determine whether phosphoric acid etching alone provides reliable adhesion. Material and Methods Four experimental materials (G‐Fix, Light Fix, Ortho Connect, and Ortho Connect Flow) were compared
Wonkyu Shin, Ji‐Soo Song, Hyuntae Kim, Wonjoon Moon, Teo Jeon Shin, Shin Hye Chung, Jin‐Soo Ahn, Hong‐Keun Hyun   +7 more
wiley   +1 more source

Arched Needle Technique for Inferior Alveolar Mandibular Nerve Block [PDF]

Journal of Maxillofacial and Oral Surgery, 2013
Although, needle breakage remains a rare complication during oral local anesthesia (LA) administration, there are ample reports mandating a careful technique and precautionary measures to prevent this complication [1–4]. Chakranarayan and Mukherjee [5] describe a method of inferior alveolar nerve block (IANB) by injecting a local anesthetic solution ...
openaire   +2 more sources

A Checklist‐Based Assessment of Manual Skill Competency in Dental Anaesthesia Using a Simulator: A Prospective, Blinded, Video‐Assisted Validation Study

European Journal of Dental Education, EarlyView.
ABSTRACT Background There is a growing need for standardised, objective methods to assess manual skills in dental procedures requiring local anaesthesia. This prospective, video‐based observational study aimed to evaluate the manual skills and clinical competence of undergraduate dental students in performing inferior alveolar nerve block (IANB) and ...
Esra Yuce
wiley   +1 more source

A Large Cheek Hematoma as a Complication of Local Anesthesia: Case Report

Acta Stomatologica Croatica, 2018
Hematoma is among less frequent complications which occur following local anesthesia. The posterior superior alveolar nerve block and inferior alveolar nerve block are known to be accompanied with a higher incidence of positive aspiration compared to all
Josip Biočić, Davor Brajdić, Berislav Perić, Petar Đanić, Ivan Salarić, Darko Macan   +5 more
doaj   +1 more source

Orofacial pain disorder or trigeminal autonomic cephalalgia? Insights into pathophysiology and implications in medicine and dentistry

Headache: The Journal of Head and Face Pain, EarlyView.
There are some headache disorders known as trigeminal autonomic cephalalgias (TACs). When these “headaches” are localized in the mid‐face region, they are known as “trigeminal autonomic orofacial pains” (TAOPs), and they can mimic other types of face pains including dental pain, which puts the patient at risk of receiving treatments that are incorrect.
Marcela Romero‐Reyes, Simon Akerman
wiley   +1 more source

Machine Learning Model for Predicting Postoperative Pain in Cases of Irreversible Pulpitis

International Endodontic Journal, EarlyView.
ABSTRACT Aim Postoperative pain is a frequent clinical concern following endodontic treatment. This study aimed to develop and validate supervised machine learning models to predict the occurrence of postoperative pain in cases of irreversible pulpitis.
Pedro Felipe de Jesus Freitas, Ingrid Luiza Mendonça Cunha, Thalita de Paris Matos, Flares Baratto‐Filho, Bianca Marques de Mattos de Araujo, Manoel Damião Sousa‐Neto, Leandro de Moura Martins, Fernando José Herkrath, Emílio Carlos Sponchiado‐Júnior, Cristiano Miranda de Araujo   +9 more
wiley   +1 more source

Significance of localization of mandibular foramen in an inferior alveolar nerve block

Journal of Natural Science, Biology and Medicine, 2012
The mandibular foramen (MF) is an opening on the internal surface of the ramus for divisions of the mandibular vessels and nerve to pass. The aim of this study is to determine the position of the MF from various anatomical landmarks in several dry adult mandibles.A total of 102 human dry mandibles were examined, of which 93 were of dentulous and 9 were
Thangavelu, K., Kannan, R., Kumar, N. Senthil, Rethish, E., Sabitha, S., SayeeGanesh, N.   +5 more
openaire   +3 more sources

Ethylenediaminetetraacetic Acid and Other Dentine Bioactive Molecule‐Releasing Agents for Regenerative Endodontic Procedures: A Systematic Review

International Endodontic Journal, EarlyView.
ABSTRACT Background The bioactive molecules released from dentine are key to stem‐cell recruitment, proliferation and differentiation in regenerative endodontics. However, there is limited and conflicting information regarding current and potential agents for releasing dentine bioactive molecules for regenerative endodontic procedures.
Arwa Al‐Maswary, Xiaoxuan Deng, Haizal M. Hussaini, Lara T. Friedlander, Paul R. Cooper   +4 more
wiley   +1 more source

Two‐Year Outcome of Partial Pulpotomy Using Mineral Trioxide Aggregate or a Premixed Calcium Silicate Cement: A Randomized Clinical Trial

International Endodontic Journal, EarlyView.
ABSTRACT Aim To compare the clinical and radiographic outcomes of partial pulpotomy performed with mineral trioxide aggregate (White MTA Angelus) or a premixed calcium silicate‐based putty cement (NeoPutty) in mature mandibular molars with deep carious lesions and to explore factors associated with treatment outcome.
Alberto Serrano, Emmanuel João Nogueira Leal Silva, Henry F. Duncan, Antonio Jesús Conde Villar, Gaizka Loroño, Roberto Estévez, Claudia Brizuela, Ruth Pérez Alfayate   +7 more
wiley   +1 more source