Results 61 to 70 of about 44,653 (215)

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats [PDF]

, 2014
Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to ...
Abdala, Ana Paula, Mill, José Geraldo, Moraes, Davi José de Almeida, Passamani, Luciana Mesquita, Paton, Julian Francis Richmond, Sampaio, Karla Nívea   +5 more
core   +5 more sources

Large Hydatid Cyst in the Cardiac Interventricular Septum: A Rare Case Report and Literature Review

Journal of Clinical Ultrasound, EarlyView.
Hydatid disease is a parasitic disease with a high incidence in pastoral areas in Tibet. The heart is an uncommon location of echinococcosis, and involvement of the interventricular septum is even rarer. This disease can remain asymptomatic for a long time, but may result in cardiac tamponade and sudden death.
Lin Gao, Yixiu Zhang, Xiao Yang
wiley   +1 more source

Cardiac MR Fingerprinting at 0.55T Using a Deep Image Prior for Joint T1, T2, and M0 Mapping

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background 0.55T systems offer unique advantages and may support expanded access to cardiac MRI. Purpose To assess the feasibility of 0.55T cardiac MR Fingerprinting (MRF), leveraging a deep image prior reconstruction to mitigate noise. Study Type Phantom and prospective in vivo assessment.
Zhongnan Liu, Zexuan Liu, Imran Rashid, Mauricio Stanzione Galizia, Christopher Scoma, William Truesdell, Prachi Agarwal, Nicole Seiberlich, Liyue Shen, Jesse Hamilton   +9 more
wiley   +1 more source

ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]

, 2015
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore, Mueller, T., Richards, Am   +2 more
core   +1 more source

Improved Myocardial Sodium Quantification at 7 T Using Interleaved 23Na/1H pTx MRI With Motion and Anatomy‐Based B1 Correction

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve accuracy and repeatability of myocardial 23Na quantification in cardiac MRI at 7 T by combining retrospective respiratory and cardiac motion correction with a novel anatomy‐based B1 bias field correction. Methods In this study, a dual‐nuclear interleaved 23Na/1H MRI sequence at 7 T was applied.
Laurent Ruck, Nico Egger, Benedikt Zobler, Judith Schirmer, Sophia Nagelstraßer, Andreas Bitz, Tanja Platt, Simon Konstandin, Christoph Kopp, Michael Uder, Armin Michael Nagel   +10 more
wiley   +1 more source

Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method [PDF]

, 2014
Detailed models of the biomechanics of the heart are important both for developing improved interventions for patients with heart disease and also for patient risk stratification and treatment planning.
Berry, Colin, Carrick, David, Gao, Hao, Griffith, Boyce E., Luo, Xiaoyu   +4 more
core   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Prognostic implications of left ventricular global longitudinal strain in heart failure patients with narrow QRS complex treated with cardiac resynchronization therapy: a subanalysis of the randomized EchoCRT trial [PDF]

, 2016
Aim: Left ventricular (LV) global longitudinal strain (GLS) reflects LV systolic function and correlates inversely with the extent of LV myocardial scar and fibrosis.
Abraham, William T., Bax, Jeroen J., Borer, Jeffrey S., Brugada, Josep, Delgado, Victoria, Dickstein, Kenneth, Ford, Ian, Gorcsan, John, Gras, Daniel, Holzmeister, Johannes, Krum, Henry, Robertson, Michele, Ruschitzka, Frank, Singh, Jagmeet P., Sogaard, Peter   +14 more
core   +2 more sources

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source