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Letrozole for Female Infertility [PDF]
Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction.
Guimin Hao+3 more
openaire +5 more sources
Genetics of Human Female Infertility
AbstractAbout 10% of women of reproductive age are unable to conceive or carry a pregnancy to term. Female factors alone account for at least 35% of all infertility cases and comprise a wide range of causes affecting ovarian development, maturation of oocytes, and fertilization competence, as well as the potential of a fertilized egg for ...
Svetlana A Yatsenko, Aleksandar Rajkovic
openaire +7 more sources
Female infertility: which role for obesity? [PDF]
Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium ...
A. Gambineri+6 more
semanticscholar +3 more sources
The role of endocrine disruptors in female infertility
Introduction According to the World Health Organization, infertility is a public health problem that affects around 48 million couples and 186 million individuals worldwide.
Ana Beatriz P Silva+3 more
semanticscholar +1 more source
Background: Although observational studies have demonstrated that blood lipids are associated with female infertility, the causality of this association remains unclear.
Xiaoqi Zhu+7 more
semanticscholar +1 more source
Association between weight-adjusted-waist index and female infertility: a population-based study
Aims Obesity is detrimental to infertility. The association between weight-adjusted-waist index (WWI, a recently developed adiposity indicator) and infertility has not previously been confirmed.
Zujun Wen, Xia Li
semanticscholar +1 more source
Dexamethasone As a Supplement for Exogenous Gonadotropin to Improve Ovarian Response of Women over 35 Years Undergoing IVF/ICSI Cycles [PDF]
Background: With aging, the ovarian reserve is decreased and that is a major contributor to poor ovarian response to exogenous gonadotropins. The aim of the present study is to evaluate the role of Dexamethasone on ovarian response in infertile patients ...
Mahnaz Ashrafi+4 more
doaj +1 more source
Role of m6A modification in female infertility and reproductive system diseases
Gamete abnormalities and reproductive system tumors have become a dominant cause of infertility, troubling people globally. In recent years, increasing evidence emerged and found that N6-methyladenosine (m6A) played a leading role in reproduction.
Jinyu Chen+3 more
semanticscholar +1 more source
The Pregnancy Outcomes of Day 2 versus Day 3 Embryo Transfer: A Cross-Sectional Study [PDF]
Background: The objective was to evaluate whether extending the embryo culture period from 2 to 3 days would yield a more optimal selection of viable embryos, thereby increasing the pregnancy rate.Materials and Methods: We have retrospectively analyzed ...
Mahnaz Ashrafi+3 more
doaj +1 more source
Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome
The regulation of the female reproductive system is one of the most relevant actions of thyroid hormones. Adequate thyroid hormones production is essential for normal menstrual function and fertility as well as for the successful maintenance of pregnancy.
I. Bucci+4 more
semanticscholar +1 more source