Results 101 to 110 of about 262,466 (282)
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Output regulation of infinite-dimensional time-delay systems
2017 American Control Conference (ACC), 2017 We study output tracking and disturbance rejection for linear infinite-dimensional time-delay systems using dynamic error feedback controllers with state delays. The class of systems covers many partial differential equations with state, input, and output delays.
openaire +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Impulsive evolution inclusions with infinite delay and multivalued jumps [PDF]
Surveys in Mathematics and its Applications, 2012 In this paper we prove the existence of a mild solution for a class of impulsive semilinear evolution differential inclusions with infinite delay and multivalued jumps in a Banach space.
Mouffak Benchohra, Mohamed Ziane
doaj
Stability in functional-differential equations with infinite delay
Tohoku Mathematical Journal, 1985 The purpose of this paper is to discuss the (uniform) asymptotic stability of a solution of functional differential equations with infinite delay by using the method of Lyapunov-Razumikhin type. To do this, we shall take the following approach: First we decompose a given equation with infinite delay as a sum of an equation with finite delay and the ...
openaire +2 more sources
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Acousto-ultrasonic input-output characterization of unidirectional fiber composite plate by P waves [PDF]
The single reflection problem for an incident P wave at a stress free plane boundary in a semi-infinite transversely isotropic medium whose isotropic plane is parallel to the plane boundary is analyzed.
Liao, Peter, Williams, James H., Jr.
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source