Results 91 to 100 of about 109,495 (298)

Generalized two-field α-attractor models from the hyperbolic triply-punctured sphere

Nuclear Physics B, 2018
We study generalized two-field α-attractor models whose rescaled scalar manifold is the triply-punctured sphere endowed with its complete hyperbolic metric, whose underlying complex manifold is the modular curve Y(2). Using an explicit embedding into the
Elena Mirela Babalic, Calin Iuliu Lazaroiu   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On potentiality, discretization, and integral invariants of the infinite-dimensional Birkhoff systems [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
In the study of the equations of motion of systems of various physical nature, there are problems in determining the qualitative indicators and properties of motion according to the known structure and properties of the equations under consideration ...
Savchin, Vladimir Mikhailovich, Trinh, Phuoc Toan   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

CNES – Chalmers – IAP – ONERA - XLIM activities in the domain of high RF power breakdown phenomena

EPJ Web of Conferences, 2017
Multipactor breakdown is an important potential failure mechanism in many different microwave devices working under close to vacuum conditions. Applications range from space borne RF equipment to high-power microwave generators.
Puech J., Sorolla E., Semenov V.E., Rakova E.I., Anderson D., Belhaj M., Hillairet J.   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

$$\mathscr{P}\mathscr{T}$$ P T -symmetric KdV solutions and their algebraic extension with zero-width resonances

Scientific Reports
A class of complex breather and soliton solutions to both KdV and mKdV equations are identified with a Pöschl-Teller type $$\mathscr{P}\mathscr{T}$$ P T -symmetric potential. However, these solutions represent only the unbroken- $$\mathscr{P}\mathscr{T}$$
Kumar Abhinav, Aradhya Shukla, Prasanta K. Panigrahi   +2 more
doaj   +1 more source

The time-independent Schrodinger equation with Dirac delta potentials in an infinite potential well [PDF]

The infinite potential well is one of the most well-known models in quantum mechanics, as well as the Dirac delta potential. In the first part of the thesis, one Dirac delta potential is considered using the time-independent Schr\ {o}dinger equation, the
Craig, Samantha M
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source