Results 81 to 90 of about 178,070,624 (286)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Existence of the time periodic solutions of system of oscillators on 2D-lattice

Karpatsʹkì Matematičnì Publìkacìï, 2013
It is considered the system of differential equations that describes the dynamics of an infinite system of oscillators on 2D-lattice. Results on existence of the time periodic solutions are obtained.
S. M. Bak
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Multi-Pursuer and One-Evader Evasion Differential Game with Integral Constraints for an Infinite System of Binary Differential Equations

Mathematics
In the Hilbert space l2, a differential evasion game involving multiple pursuers is considered. Integral constraints are imposed on player control functions.
Ruzakhon Kazimirova, Gafurjan Ibragimov, Bruno Antonio Pansera, Abdulla Ibragimov   +3 more
doaj   +1 more source

Hybrid Fixed Point Theorem with Applications to Forced Damped Oscillations and Infinite Systems of Fractional Order Differential Equations

Journal of Function Spaces, 2020
In this manuscript, hybrid common fixed point results in the setting of a b-metric space are established. Our results generalized the results of Fisher, Khan, and Piri et al. for set-valued mapping in b-metric spaces.
Muhammad Shoaib, Muhammad Sarwar, Thabet Abdeljawad   +2 more
doaj   +1 more source

Nonlocal Inverse Problem for a Pseudohyperbolic- Pseudoelliptic Type Integro-Differential Equations

Axioms, 2020
The questions of solvability of a nonlocal inverse boundary value problem for a mixed pseudohyperbolic-pseudoelliptic integro-differential equation with spectral parameters are considered.
Tursun K. Yuldashev
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Maximal Regularity Estimates and the Solvability of Nonlinear Differential Equations

, 2022
We study a type of third-order linear differential equations with variable and unbounded coefficients, which are defined in an infinite interval. We also consider a non-linear generalization with coefficients that depends on an unknown function.
Myrzagali Ospanov, Kordan Ospanov
core   +1 more source