Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Paradox of the Sub-Plankton: Plausible Mechanisms and Open Problems Underlying Strain-Level Diversity in Microbial Communities. [PDF]
Goyal A, Chure G.
europepmc +1 more source
Points and lines inside human brains. [PDF]
Tozzi A, Peters JF.
europepmc +1 more source
Psychology's Questionable Research Fundamentals (QRFs): Key problems in quantitative psychology and psychological measurement beyond Questionable Research Practices (QRPs). [PDF]
Uher J +11 more
europepmc +1 more source
Statistical characterization of the linear attenuation coefficient in polychromatic CT scans. [PDF]
Vegas G, San José Estépar R.
europepmc +1 more source
ABSTRACT Excessive water production in mature oil fields necessitates robust shut‐off treatments, yet conventional polymer gels often fail under high‐temperature and high‐salinity conditions. This study aims to enhance gel thermal stability and mechanical strength by incorporating selenium‐doped Ag/AgO–ZnO nanocomposites synthesized via a novel green ...
Fadhil F. Sead +8 more
wiley +1 more source
Complexity Analysis of Bubble Plumes in Power Law Fluids Based on Chaos Theory
ABSTRACT In order to reveal the complexity of the internal flow of bubble plume in power law fluid, the flow characteristics and chaotic characteristics of plume are studied by experiment and theory. The chaotic characteristic parameters (correlation dimension D, K entropy, and Lyapunov exponent λ) of gas velocity under different superficial gas ...
Xin Dong +6 more
wiley +1 more source
A Hybrid Semi‐Inverse Variational and Machine Learning Approach for the Schrödinger Equation
A hybrid semi‐inverse variational and machine‐learning framework is presented for solving the Schrödinger equation with complex quantum potentials. Physics‐based variational solutions generate high‐quality training data, enabling Random Forest and Neural Network models to deliver near‐perfect energy predictions.
Khalid Reggab +5 more
wiley +1 more source
Shrinkage priors for isotonic probability vectors and binary data modeling, with applications to dose-response modeling. [PDF]
Boonstra PS, Owen DR, Kang J.
europepmc +1 more source
Abstract Differences in skull and tooth morphology, stomach contents, and estimated bite force between medium‐to‐large sized (≥100 kg) predatory theropod dinosaurs have long been suspected to correlate with differences in their diets and dietary guilds (e.g., hypercarnivory, piscivory).
Cassius Morrison +9 more
wiley +1 more source

