Results 31 to 40 of about 946,958 (320)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Infinitely many periodic solutions for a class of fractional Kirchhoff problems

, 2019
We prove the existence of infinitely many nontrivial weak periodic solutions for a class of fractional Kirchhoff problems driven by a relativistic Schr\"odinger operator with periodic boundary conditions and involving different types of ...
Ambrosio, Vincenzo
core   +1 more source

Existence of infinitely many solutions for a nonlocal elliptic PDE involving singularity [PDF]

Positivity (Dordrecht), 2018
In this article, we will prove the existence of infinitely many positive weak solutions to the following nonlocal elliptic PDE. (-Δ)su=λuγ+f(x,u)inΩ,u=0inRN\Ω,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts ...
Sekhar Ghosh, D. Choudhuri
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Infinitely many positive solutions for a double phase problem

Boundary Value Problems, 2020
This paper is concerned with the existence of infinitely many positive solutions to a class of double phase problem. By variational methods and the theory of the Musielak–Orlicz–Sobolev space, we establish the existence of infinitely many positive ...
Bei-Lei Zhang, Bin Ge, Gang-Ling Hou
doaj   +1 more source

Infinitely Many Strings in De Sitter Spacetime: Expanding and Oscillating Elliptic Function Solutions

, 1993
The exact general evolution of circular strings in $2+1$ dimensional de Sitter spacetime is described closely and completely in terms of elliptic functions.
A.L. Larsen, Abramowitz, de Vega, de Vega, de Vega, de Vega, Gasperini, Gasperini, Gradshteyn, H.J. de Vega, N. Sánchez, Sánchez, Sánchez   +12 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Infinitely many solutions to Kirchhoff double phase problems with variable exponents [PDF]

Applied Mathematics Letters, 2022
Ky Ho, Patrick Winkert
semanticscholar   +1 more source

Infinitely many solutions for impulsive fractional boundary value problem with p-Laplacian

Boundary Value Problems, 2018
This paper deals with the existence of infinitely many solutions for a class of impulsive fractional boundary value problems with p-Laplacian. Based on a variant fountain theorem, the existence of infinitely many nontrivial high or small energy solutions
Yang Wang, Yansheng Liu, Yujun Cui
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source