Results 11 to 20 of about 3,477 (115)
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Antioxidants, 2022 Prostate cancer (PCa) cells display abnormal expression of proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown the anti-tumoral role of heme oxygenase 1 (HO-1) in this disease.
Sofia Lage-Vickers +13 more
doaj +1 more source
Conditioned serum in vitro treatment of chondrocyte pellets and osteoarthritic explants
Equine Veterinary Journal, Volume 55, Issue 2, Page 325-335, March 2023., 2023 Abstract Background Autologous conditioned serum (ACS) is used to treat osteoarthritis in horses, although its effects are not fully investigated. Objectives To investigate the effects of equine serum and conditioned serum on chondrocytes stimulated with interleukin (IL)‐1β and cartilage explants with mild osteoarthritis.
Maria Löfgren +8 more
wiley +1 more source
EDIS, 2020 La inflamación es la respuesta de su cuerpo a las lesiones e infecciones – así es como su sistema inmunológico ayuda a protegerlo de cualquier daño. Por el contrario, la inflamación crónica contribuye a muchas enfermedades, como enfermedades cardíacas ...
Daniela Rivero-Mendoza, Wendy J. Dahl
doaj +5 more sources
The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer
Communications Biology, 2021 Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression.
Sofia Lage-Vickers +12 more
doaj +1 more source
Frontiers in Immunology, 2021 Background and AimsGM-CSF-dependent macrophage polarization has been demonstrated in rheumatoid arthritis (RA). Our aim was to seek diagnostic/prognostic biomarkers for undifferentiated arthritis (UA) by analyzing GM-CSF expression and source, macrophage
Sara Fuentelsaz-Romero +9 more
doaj +1 more source
Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus
Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021 Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck +6 more
wiley +1 more source
Biomolecules, 2020 The inflammatory tumor microenvironment is a fertile niche accelerating prostate cancer (PCa). We have reported that heme-oxygenase (HO-1) had a strong anti-tumoral effect in PCa.
Emiliano Ortiz +8 more
doaj +1 more source
Mast Cells in Immune-Mediated Cholangitis and Cholangiocarcinoma
Cells, 2022 Cholestasis, which is impaired bile flow from the liver into the intestine, can be caused by cholangitis and/or bile duct obstruction. Cholangitis can arise from bacterial infections and cholelithiasis, however, immune-mediated cholangitis in primary ...
Marisol I. González +4 more
doaj +1 more source
Veterinary Dermatology, Volume 32, Issue 4, Page 331-e92, August 2021., 2021 Background MicroRNAs (miRNA) are short, single‐stranded RNA molecules that regulate gene expression in a post‐transcriptional manner. Their expression is proposed to be tissue‐specific and alterations in miRNA expression have been detected in many diseases. Objective To compare miRNA expression in the skin of healthy Labrador and golden retrievers, and
Marie Isabel Morlang +3 more
wiley +1 more source