Results 281 to 290 of about 90,432 (374)

Ricin Toxin Activates the NALP3 Inflammasome [PDF]

, 2010
Meghan Lindauer, John Wong, Bruce E. Magun   +2 more
openalex   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Targeting inflammasomes as a therapeutic potential for HIV/AIDS. [PDF]

Cell Mol Life Sci
Zhang H, Tan B, Tang T, Tao J, Jin T, Wu S.   +5 more
europepmc   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cardio-Rheumatic Diseases: Inflammasomes Behaving Badly. [PDF]

Int J Mol Sci
Issa F, Abdulla M, Retnowati FD, Al-Khawaga H, Alhiraky H, Al-Harbi KM, Al-Haidose A, Maayah ZH, Abdallah AM.   +8 more
europepmc   +1 more source

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

, 2010
Teresa Fernandes‐Alnemri, Je‐Wook Yu, Christine A. Juliana, Leobaldo Solórzano, Seokwon Kang, Jianghong Wu, Pinaki Datta, Margaret E. McCormick, Lan Huang, Erin McDermott, Laurence C. Eisenlohr, Carlisle P. Landel, Emad S. Alnemri   +12 more
openalex   +2 more sources

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Sulphonylureas as Adjunct Therapeutic Agents in the Treatment of Autoimmune Conditions: A Narrative Review. [PDF]

Pharmacol Res Perspect
Elford J, O'Reilly RJ, Babey AM, Rafeek RAM, Ketheesan N.   +4 more
europepmc   +1 more source

IL-1β Processing in Host Defense: Beyond the Inflammasomes

, 2010
Mihai G. Netea, Anna Simon, Frank L. van de Veerdonk, Bart Jan Kullberg, Jos W.M. van der Meer, Leo A. B. Joosten   +5 more
openalex   +2 more sources