Results 291 to 300 of about 90,432 (374)

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Regulation of antiviral and antimicrobial innate immunity and immune evasion. [PDF]

Cell Mol Life Sci
Wang L, He D, Satoh-Takayama N, Zheng C, Xing J.   +4 more
europepmc   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1485-1489, April 2025.
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Sanjay Divakaran, Vinay Randhawa, Usman A. Tahir, Matthew Robertson, Anam A. Waheed, Anna Perillo, Leanne Barrett, Ron Blankstein, Mark W. Feinberg, Marcelo F. Di Carli, Neal K. Lakdawala   +10 more
wiley   +1 more source

Fenofibrate mitigates the dysfunction of high glucose-driven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome. [PDF]

Int J Ophthalmol
Shi Y, Chen HM, Liu AH, Li XR.
europepmc   +1 more source

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

, 2010
Alana A. Shigeoka, James L. Mueller, Amanpreet Kambo, John C. Mathison, Andrew J. King, Wesley F. Hall, Jean da Silva Correia, Richard J. Ulevitch, Hal M. Hoffman, Dianne B. McKay   +9 more
openalex   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

ESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori, Sergio Davinelli, Armando Ferrera, Alessandro Medoro, Carlo Barsali, Allegra Battistoni, Maurizio Volterrani, Massimo Volpe, Luciano Saso, Speranza Rubattu   +9 more
wiley   +1 more source

The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk. [PDF]

Sci Adv
Gao H, Wang L, Lyu Y, Jin H, Lin Z, Kang Y, Li Z, Zhang X, Jiang Y, Zhang G, Tao Z, Zhang X, Yang B, Bai X, Ma X, Liu S, Jiang J.   +16 more
europepmc   +1 more source

Circulating oxylipins predict mortality in heart failure with preserved ejection fraction

ESC Heart Failure, EarlyView.
A targeted LC–MS lipidomics approach identified arterial 15‐keto PGF2a as associated with 5‐year mortality in 90 patients with HFpEF. Abstract Aims Heart failure with preserved ejection fraction (HFpEF) poses significant diagnostic, prognostic and therapeutic challenges, with high morbidity and mortality rates.
Vaishnavi Aradhyula, Sareeta Manandhar, Alborz Sherafati, Alex Kloster, Anas Fares, Prabhatchandra Dube, Pamela S. Brewster, George V. Moukarbel, Krishna Rao Maddipati, Steven T. Haller, David J. Kennedy, Rajesh Gupta, Samer J. Khouri   +12 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells. [PDF]

Sci Rep
Wang X, Tian H, Chen S, Ying L, Zheng J, Song Y, Xi J, Zhang Y, Wang D.   +8 more
europepmc   +1 more source

Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome

, 2010
Edward A. Miao, Sarah Warren
openalex   +2 more sources