Results 341 to 350 of about 4,367,929 (381)

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Histologic and Endoscopic Findings Are Highly Correlated in a Prospective Cohort of Patients With Inflammatory Bowel Diseases. [PDF]

J Crohns Colitis
Di Vincenzo F, Quintero MA, Serigado JM, Koru-Sengul T, Killian RM, Poveda J, England J, Damas O, Kerman D, Deshpande A, Abreu MT.   +10 more
europepmc   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Targeting inflammatory pathways in hepatocellular carcinoma: recent developments. [PDF]

Discov Oncol
Ramaite FT, Nkadimeng SM.
europepmc   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Inflammatory indices AISI and SIRI in atherosclerosis risk stratification: validation across community and intensive care populations. [PDF]

Ann Med
Tang J, Li TX, Deng L, Huang XC, He PY, Zhao H.   +5 more
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Prospective Associations Between Salivary Biomarkers of Inflammation and Body Mass Index in Adolescents. [PDF]

Obes Sci Pract
Kemp KM, Orihuela CA, Granger DA, Evans RR, Mrug S.   +4 more
europepmc   +1 more source

MK2 Inhibition as a Novel Treatment for Fibrosis in Primary Sclerosing Cholangitis via an IL-22-Dependent Mechanism. [PDF]

Cells
Howe CS, Beswick EJ.
europepmc   +1 more source

cGAS-STING Targeting Offers Novel Therapeutic Opportunities in Liver Diseases. [PDF]

Drug Des Devel Ther
Wang Y, Yang R, Cao Y, Li Y, Zhu Y, Zhang Z, Fleishman JS, Chen J, Ding M.   +8 more
europepmc   +1 more source