Results 61 to 70 of about 47,766 (237)

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients with Eosinophilic Granulomatosis with Polyangiitis

Arthritis &Rheumatology, Accepted Article.
Objective The Phase 3 MANDARA study demonstrated non‐inferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair, Bernhard Hellmich, Arnaud Bourdin, David R. W. Jayne, Florence Roufosse, Nader Khalidi, Lena Börjesson Sjö, Ying Fan, Christopher McCrae, Sofia Necander, Eva Rodríguez‐Suárez, Anat Shavit, Claire Walton, Peter A. Merkel, Michael E. Wechsler   +14 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

AB1331 COVID VACCINATION AND ADVERSE REACTIONS AMONG PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES: WHAT IS THE RHEUMATOLOGIST’S ROLE? [PDF]

, 2023
Ana Valle, S. Mahmood
openalex   +1 more source

Transforming Pharmacovigilance With Pharmacogenomics: Toward Personalized Risk Management

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is a critical component of medication safety. Despite rigorous evaluation of new drugs during clinical trials, some adverse effects might only be identified once pharmaceuticals are used by a larger population for a longer duration.
Claire Spahn, Nanase Toda, Blaine Groat, Omar Aimer, Sara Rogers, Akinyemi Oni‐Orisan, Andrew Monte, Nancy Hakooz, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +8 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Anti-nuclear matrix protein 2 antibody-positive idiopathic inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash [PDF]

, 2021
Yuki Ichimura, Miwako Shobo, Sae Inoue, Mari Okune, Akemi Maeda, Ryota Tanaka, Noriko Kubota, Isao Matsumoto, Akiko Ishii, Akira Tamaoka, Asami Shimbo, Masaaki Mori, Tomohiro Morio, Takayuki Kishi, Takako Miyamae, Jantima Tanboon, Michio Inoue, Ichizo Nishino, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama   +20 more
openalex   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

A Case Report of Inflammatory Myopathy and Sideroblastic Anemia

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2007
Mitochondrial myopathy, lactic acidosis, and siderobastic anemia (MLA SA) syndrome is one of the newly reported mitochondrial diseases, seven cases of which have been reported. We report a child with inflammatory myopathy, sideroblastic anemia and lactic
F Binesh, M Mortazavi Zadeh, R Fallah
doaj  

Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis

ESC Heart Failure, EarlyView.
Epicardial adipose tissue (EAT) has been linked to adverse remodelling and outcomes in aortic valve stenosis (AS), yet mechanisms remain unclear. In 137 patients with severe AS undergoing CMR before TAVR, higher EAT (≥46.5 ml/m2) was associated with impaired left atrial (LA) reservoir strain, while ventricular morphology, function and tissue ...
Judith Gronwald, Torben Lange, Sören J. Backhaus, Bo E. Beuthner, Ruben Evertz, Miriam Puls, Johannes T. Kowallick, Karl Toischer, Gerd Hasenfuß, Andreas Schuster, Alexander Schulz   +10 more
wiley   +1 more source

Anti-HMGCR myopathy: a first case report from North Africa and literature insights

Frontiers in Immunology
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is a rare idiopathic inflammatory myopathy characterized by severe muscle damage and minimal extra-muscular involvement.
Houssem Abida, Houssem Abida, Imen Zamali, Imen Zamali, Imen Zamali, Imène Rachdi, Imène Rachdi, Zakaria Saied, Zakaria Saied, Ahlem Ben Hmid, Ahlem Ben Hmid, Ahlem Ben Hmid, Samar Samoud, Samar Samoud, Yousr Galai, Fatma Daoud, Fatma Daoud, Fatma Boussema, Fatma Boussema, Samia Ben Sassi, Samia Ben Sassi, Zohra Aydi, Zohra Aydi, Mélika Ben Ahmed, Mélika Ben Ahmed, Mélika Ben Ahmed   +25 more
doaj   +1 more source