Results 161 to 170 of about 1,221,115 (332)
Aging and the Spectral Properties of Brain Hemodynamics
As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park+9 more
wiley +1 more source
NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong+18 more
wiley +1 more source
China’s constantly rapid economic growth accompanying by a low overall inflation has long been mysterious in macroeconomics. The core purpose of this paper is to solve this puzzle.
Dayu Liu, Bin Xu, Yang Song, Tingyu Liu
doaj +1 more source
The continental‐scale study reveals that soil phosphorus strongly predicts the richness of soil pathogenic oomycetes in Chinese grasslands, while precipitation and plant species richness drive their absolute abundance; modeling predicts ≈42% of grassland areas may face elevated oomycete disease risk under future climate scenarios, especially in typical
Junsheng Ke+10 more
wiley +1 more source
Inflation-income inequality nexus in South Africa: the role of inflationary environment
We estimate vector autoregressive models to examine the effect of the 3 to 6 per cent inflation target band in the inflation and income inequality nexus in South Africa.
Eliphas Ndou
doaj +1 more source
Summaries of Addresses of Presidents of Sections: Open and Repressed Monetary Inflation [PDF]
openalex +1 more source
A Complementarity‐Based Approach to De Novo Binder Design
A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko+17 more
wiley +1 more source
Are Variable Annuities the Answer to Inflation? [PDF]
Paul W. McCracken
openalex +1 more source
Embodying Control in Soft Multistable Robots from Morphofunctional Co‐design
A framework is introduced for co‐designing the morphology and planned tasks of soft robots by embodying specific reconfiguration modes and dynamics upon actuation, leveraging an efficient energy‐based analytical model and optimization. Desired kinematics are co‐designed with optimized stiffnesses and time responses to obtain robots capable of ...
Juan C. Osorio+3 more
wiley +1 more source