Results 181 to 190 of about 445,748 (288)

Performance of a zero-inertia model for irrigation with rapidly varied inflow discharges [PDF]

open access: gold, 2020
Kaihua Liu   +6 more
openalex   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin   +14 more
wiley   +1 more source

A forensic engineering framework for flood management of cascade reservoir systems. [PDF]

open access: yesSci Rep
Zeinali M   +5 more
europepmc   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang   +10 more
wiley   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

open access: yesAdvanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao   +9 more
wiley   +1 more source

Largest documented cerebral aneurysm mimicking a giant brain tumor and treated by highly selective occlusion of inflow: illustrative case. [PDF]

open access: yesJ Neurosurg Case Lessons
Andereggen L   +10 more
europepmc   +1 more source

Liquid Crystal‐Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors

open access: yesAdvanced Science, EarlyView.
This work introduces a liquid crystal (LC)‐based platform for dynamic chemical feeding in droplet microreactors, enabling unprecedented control over reaction kinetics and mass transfer. By leveraging LC phase transition‐mediated release, new pathways are unlocked for enhancing confined reaction environments, advancing the fundamental capabilities of ...
Yang Xu   +5 more
wiley   +1 more source

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