Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong +21 more
wiley +1 more source
Irrigated agriculture influences selenium levels in an endangered marsh bird. [PDF]
Yost CM +4 more
europepmc +1 more source
Comment on “Influence of sea level rise on the dynamics of salt inflows in the Baltic Sea” by R. Hordoir, L. Axell, U. Löptien, H. Dietze, and I. Kuznetsov [PDF]
Lars Arneborg
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This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun +15 more
wiley +1 more source
Numerical study of the performance of a three-phase horizontal separator under varying water outlet pressures. [PDF]
Shin HC, Hwang I, Jang HL, Seo H.
europepmc +1 more source
Groundwater Dynamic Method and Parameter Analysis of Tunnel Water Inflow
Guifang Zhang, Duoxi Yao
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Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma +11 more
wiley +1 more source
Fatal tricuspid valve inflow obstruction and inferior vena cava syndrome in a child with advanced Wilms' tumor: a case report. [PDF]
Gimonge J, Muhunzi D, Nkya D.
europepmc +1 more source

