Results 241 to 250 of about 431,047 (332)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Amplitude fluctuations of cerebrovascular oscillations and CSF movement desynchronize during NREM3 sleep. [PDF]

J Cereb Blood Flow Metab
Nair VV, Kish BR, Oshima H, Wright AM, Wen Q, Schwichtenberg AJ, Tong Y.   +6 more
europepmc   +1 more source

Probing the Challenge of P‐Type Semiconductors in Long‐Chain VOC Detection: 3D Micro‐Flower Zinc Cobaltate Heterojunction Sensors

Advanced Science, EarlyView.
Fe@WO3/ZnCo2O4 n‐p heterojunction sensor exhibits excellent room‐temperature sensing toward tetradecane, with a low detection limit of 78.4 ppb and short recovery time. The good performance is attributed to synergistic effects from heterojunctions, heteroatom doping, oxygen vacancies, high‐energy facets, and theoretical validations.
Kewei Liu, Zichen Zheng, Yiwen Zhou, Carla Bittencourt, Marc Debliquy, Chao Zhang   +5 more
wiley   +1 more source

Machine learning approach for identifying and forecasting streamflow droughts in data limited basins of South Korea using threshold levels. [PDF]

Sci Rep
Seo YH, Sung JH, Kim BS, Park J.
europepmc   +1 more source

Methane modeling: predicting the inflow of methane gas into coal mines. Quarterly technical progress report, January 2, 1981-March 31, 1981

, 1981
C.M. Boyer, H.L. Morrison, F. C. Schwerer   +2 more
openalex   +2 more sources

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis‐Mediated DNA Repair in Osteosarcoma

Advanced Science, EarlyView.
The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang, Zhaohui Li, Lina Tang, Zhen Pan, Xiang Fei, Chen Tan, Aina He, Qingcheng Yang, Dongdong Cheng   +8 more
wiley   +1 more source

Simultaneous MRI and laser Doppler Flowmetry: Assessing cerebral Macro- and microcirculation in neurointensive care. [PDF]

Neuroimage Clin
Tapper S, Mauritzon S, Martins MP, Ginstman F, Tisell A, Zsigmond P, Wårdell K.   +6 more
europepmc   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

Utilization of a bioinspired algorithm for optimum reservoir operation in an altering climate a case study of China. [PDF]

Sci Rep
Li Q, Zhou H, Shirzad A.
europepmc   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source