Results 261 to 270 of about 431,047 (332)

Simple surgical explant technique for the EDWARDS INTUITY rapid deployment valve: a case report of prosthetic valve endocarditis. [PDF]

open access: yesGen Thorac Cardiovasc Surg Cases
Sakurai H   +6 more
europepmc   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

open access: yesAdvanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang   +13 more
wiley   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

open access: yesAdvanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen   +17 more
wiley   +1 more source

Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post‐Orthodontic Tissue Reconstruction and Relapse‐Inhibition

open access: yesAdvanced Science, EarlyView.
Orthodontic relapse persists as a 120‐year challenge, as traditional retainers fail to remodel tissue, causing lifelong dependence. This study demonstrates a flexible magnetoelectric retainer (FMOR) enabling wireless periodontal remodeling. FMOR cues shift periodontal ligament cell (PDLC) paracrine signaling, promoting M2 macrophages, osteogenic ...
Haoqi Lei   +9 more
wiley   +1 more source

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