Results 41 to 50 of about 445,748 (288)

Advancing subseasonal reservoir inflow forecasts using an explainable machine learning method

Journal of Hydrology: Regional Studies, 2023
Study RegionUpper Colorado River Basin and Great Basin in the United StatesStudy FocusAccurate subseasonal reservoir inflow forecasts and understanding the influence of hydrometeorological forcings on these forecasts are crucial for improving water ...
Ming Fan, Siyan Liu, Dan Lu
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Using a seasonal and trend decomposition algorithm to improve machine learning prediction of inflow from the Yellow River, China, into the sea

Frontiers in Marine Science
The Yellow River is the largest inflow into the Bohai Sea, and its inflow changes directly affect the ecological environment and marine health of the Bohai Sea.
Shuo Wang, Shuo Wang, Ke Yang, Ke Yang, Hui Peng, Hui Peng   +5 more
doaj   +1 more source

MONITORING THE CASH FLOWS OF THE RUSSIAN FEDERAL PENITENTIARY SERVICE (FSIN)

Финансы: теория и практика, 2017
The results of the cash flow monitoring provide managers with the information basis for making sound management decisions in terms of improving the solvency, financial condition and effectiveness of the Federal Penitentiary Service.
L. A. Malenkova
doaj   +1 more source

The application of sub‐seasonal to seasonal (S2S) predictions for hydropower forecasting

Meteorological Applications, 2022
Inflow forecasts play an integral role in the management and operations of hydropower reservoirs. In Scotland, the horizon of inflow forecasts is limited in range to approximately 2 weeks ahead.
Robert M. Graham, Jethro Browell, Douglas Bertram, Christopher J. White   +3 more
doaj   +1 more source

Estimating the characteristics of runoff inflow into Lake Gojal in ungauged, highly glacierized upper Hunza River Basin, Pakistan [PDF]

, 2013
Motivated by the potential flood outburst of Lake Gojal in the ungauged highly glacierized (27%) upper Hunza River Basin (HRB) in Pakistan that was dammed by a massive landslide on 4 January 2010, we attempt to analyze the characteristics of water inflow
Hagemann, S., Xu, J., Zhang, S., Zhao, Q.   +3 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Foreign Direct Investment and Economic Growth in Albania

ECONOMICS, 2015
Since the 1980s, foreign direct investment inflow (FDI) has grown significantly in most developing countries while pertaining Alania, foreign direct investment has started after the 1990s.
Kraja Boriçi Ylvije, Osmani Elezi
doaj   +1 more source

Rotating Accretion Flows: From Infinity to the Black Hole

, 2013
Accretion onto a supermassive black hole of a rotating inflow is a particularly difficult problem to study because of the wide range of length scales involved. There have been broadly utilized analytic and numerical treatments of the global properties of
Li, Jason, Ostriker, Jeremiah, Sunyaev, Rashid   +2 more
core   +1 more source