Results 51 to 60 of about 445,748 (288)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Effects of Continuous Rainfall and Runoff under Different Slope Conditions on Hillslope Soil Erosion in the Black Soil Region

Shuitu Baochi Xuebao
［Objective］ To investigate the characteristics of rill erosion on slopes under different slope gradients and rainfall-runoff conditions. ［Methods］ Continuous simulated rainfall and upper slope inflow tests were conducted to study the erosion processes on
WANG Tingting, SHEN Haiou, LIANG Yushi, LIU Jianxiang, ZHAO Qiang, WANG Xueying, TIAN Li   +6 more
doaj   +1 more source

Trends in FDI Movement of New Zealand Economy over the Last Two Decades: An Analysis

Journal of International Business, Economics and Entrepreneurship, 2019
Foreign Direct Investment has been the main source of capital for New Zealand economy during the last two decades. This paper analyses how FDI had changed the New Zealand economy over the years as a response to worldwide globalization.
Ershad Ali, Ronica Joyce Adriano
doaj   +1 more source

Chaos-generalized regression neural network prediction model of mine water inflow

SN Applied Sciences, 2021
Artificial neural network (ANN) provides a new way for mine water inflow prediction. However, the effectiveness of prediction using ANN model would not be guaranteed if the influencing factors of water inflow are difficult to quantify or there are only a
Jianlin Li, Luyang Wang, Xinyi Wang, Peiqiang Gao   +3 more
doaj   +1 more source

Two-dimensional Inflow-wind Solution of Hot Accretion Flow. I. Hydrodynamics [PDF]

, 2021
Amin Mosallanezhad, Fatemeh Zahra Zeraatgari, Liquan Mei, De-Fu Bu, Amin Mosallanezhad, Fatemeh Zahra Zeraatgari, Liquan Mei, De-Fu Bu   +7 more
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Estimation of mass outflow rates from dissipative accretion disc around rotating black holes

, 2017
We study the properties of the dissipative accretion flow around rotating black holes in presence of mass loss. We obtain the complete set of global inflow-outflow solutions in the steady state by solving the underlying conservation equations self ...
Aktar, Ramiz, Das, Santabrata, Nandi, Anuj, Sreehari, H.   +3 more
core   +1 more source

Anomaly inflow and RR anomalous couplings [PDF]

, 1999
We review the anomaly inflow mechanism on D-branes and O-planes. In particular, we compute the one-loop world-volume anomalies and derive the RR anomalous couplings required for their cancellation.Comment: 9 pages, LaTex, Talk given by C.A.
Scrucca, Claudio A., Serone, Marco
core   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Water circulation and recharge pathways of coastal lakes along the southern Baltic Sea in northern Poland

Limnological Review, 2016
The purpose of this paper is to describe water circulation patterns for selected lakes found along the Baltic coast in northern Poland and to determine primary recharge mechanisms or pathways that produce an influx or loss of lake water.
Cieśliński Roman, Chlost Izabela, Budzisz Marta   +2 more
doaj   +1 more source