Results 101 to 110 of about 139,233 (252)
System Quality Analysis with Extended Influence Diagrams
, 2007 Making major changes in enterprise information systems, such as large IT-investments, often have a significant impact on business operations. Moreover, when deliberating which IT-changes to make, the consequences of choosing a certain scenario may be ...
Lagerström, Robert +3 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Influence diagrams for speed profile optimization" computational issues
, 2015 Influence diagrams were applied to diverse decision problems. However, the general theory is still not sufficiently developed if the variables are continuous or hybrid and the utility functions are nonlinear.
Vomlel, Jiří
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Myopic Value of Information in Influence Diagrams
, 1997 We present a method for calculation of myopic value of information in influence diagrams (Howard & Matheson, 1981) based on the strong junction tree framework (Jensen et al., 1994) . An influence diagram specifies a certain order of observations and
Søren L. Dittmer, Finn V. Jensen
core
Approximate solution of Unconstrained influence diagrams
, 2006 We give an introduction to the theory of probabilistic graphical models and describe several types of them (Bayesian Networks - BN, Influence Diagrams - ID, Unconstrained Influence Diagrams - UID). Unconstrained Influence Diagrams support the possibility
Fried, Vojtěch
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source