Results 211 to 220 of about 593,613 (276)

Congestion loop analysis on continuous one hour traffic volume and travel time plots linked to one minute volume speed diagrams. [PDF]

Sci Rep
Fujita M, Aratani A.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Failing to succeed: advancing mechanistic understanding of implementation strategies through retrospective and prospective use of causal pathway diagrams. [PDF]

Implement Sci Commun
Austad K, Fantasia KL, Mohanty A, Jones KC, Bosch NA, Drainoni ML.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Unveiling biomarkers of telitacicept's efficacy in SLE treatment through proteomics and metabolomics. [PDF]

Front Immunol
Nie H, Chang S, Chen H, Shi J, Li S, Peng X, Cheng W, Wang J, Tang Q, Ge Y, Xie X, Li F.   +11 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Unraveling Fundamental Activity-Stability Relationships in Rutile Oxides. [PDF]

J Phys Chem C Nanomater Interfaces
Maraschin M, Gauthier JA.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Explainable machine learning for incipient anomaly detection in compact molten salt heat exchanger with overlapping feature distributions. [PDF]

Sci Rep
Prantikos K, Lee T, Hua TQ, Tsoukalas LH, Heifetz A.   +4 more
europepmc   +1 more source

Groundwater Driving Factors Identification and Its Associated Human Health Risk Assessment in a Metropolitan City of Southwest China. [PDF]

Toxics
Zhao X, Luo H, Yao R, Xie Z, Chen S, Zhang L, Zhang Y, Wang Y, Liu Y.   +8 more
europepmc   +1 more source