Results 41 to 50 of about 139,233 (252)
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Solving Influence Diagrams with Simple Propagation
, 2019 Recently, Simple Propagation was introduced as an algorithm for belief update in Bayesian networks using message passing in a junction tree. The algorithm differs from other message passing algorithms such as Lazy Propagation in the message construction ...
Oliveira, Jhonatan +3 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Possibilistic decision theory: from theoretical foundations to influence diagrams methodology
, 2012 Le domaine de prise de décision est un domaine multidisciplinaire en relation avec plusieurs disciplines telles que l'économie, la recherche opérationnelle, etc.
Guezguez, Wided
core
Decision making with decision event graphs [PDF]
, 2010 We introduce a new modelling representation, the Decision Event Graph (DEG), for asymmetric multistage decision problems. The DEG explicitly encodes conditional independences and has additional significant advantages over other representations of ...
Thwaites, Peter +2 more
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Evaluating Influence Diagrams using LIMIDs
CoRR, 2000 We present a new approach to the solution of decision problems formulated as influence diagrams. The approach converts the influence diagram into a simpler structure, the LImited Memory Influence Diagram (LIMID), where only the requisite information for the computation of optimal policies is depicted.
Nilsson, Dennis +1 more
openaire +4 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Influence Diagrams as a Tool for Decision Support System Design
, 2008 This article examines the application of a modeling technique called influence diagramming to decision support system (DSS) analysis. Influence diagrams allow the development of a model of the natural (at least from the perspective of the decision maker)
Peter O’Donnell, Rob Meredith
core +1 more source