Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. [PDF]
BACKGROUND: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the ...
GBD 2021 Risk Factors Collaborators +1 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
en:The influence of the distribution of household and childrearing tasks between men and woman on childbearing intentions in Austria [PDF]
It is the purpose of this paper to look at the extent to which the division of household work and childrearing tasks influence a couple's plans of further childbearing.
Isabelle Bubner-Ennsner
core
Facilitating sustainable energy transition of Nepal: A best-fit model to prioritize influential socio-economic and climate perception factors on household energy behaviour [PDF]
Our study investigates the relatively unexplored relationships between socio-economic factors and perceptions of climate change and their influence on household energy preferences in developing contexts, taking the case of Nepal.
Apan, Armando +3 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Program, Tampa School of Household Arts 1916 Commencement, May 29, 1916
, 1916 1916 Commencement program for the Tampa School of Household Arts held at Beulah Baptist Church.https://digitalcommons.usf.edu/armwood_records/1006/thumbnail ...
Tampa School of Household Arts
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Instructional Materials, Tampa School of Household Arts, Lesson II, circa 1915
, 1915 Lesson II from the Tampa School of Household Arts concerning hits on use and care for gas range.https://digitalcommons.usf.edu/armwood_records/1009/thumbnail ...
Tampa School of Household Arts
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source