PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Allocation of Time within Italian Couples: Exploring the Role of Institutional Factors and their Effects on Household?s Wellbeing [PDF]
taly is characterized by a very uneven distribution of paid and unpaid work in gender terms. Italy has the lowest female employment rate apart from Malta in the European region, with a tangibly wide gender gap in employment and participation rates to the
Tindara Addabbo +2 more
core
Effects of household and neighbourhood attributes on four definitions of multimorbidity: a comparative multilevel analysis of linked clinical and census data of Wales. [PDF]
BMJ Public HealthAbubakar EO +7 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Shrinking household size and CO<sub>2</sub> emissions in China evidence from machine learning and input output models. [PDF]
iScienceYu Y, Wang H, Wang H, Huang W, Qian T.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Determinants of neonatal size and body composition: protocol of a prospective cohort study of mother-newborn pairs in Bloemfontein, South Africa. [PDF]
BMJ OpenCarboo JA +3 more
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Gendered Pathways to Missed and Zero-Dose Polio Vaccination in Children: A Narrative Review of Women's Autonomy, Household Decision-Making, Structural Barriers, and Health System Responsiveness in Afghanistan, Nigeria, Pakistan, and Sudan. [PDF]
Vaccines (Basel)Musuka G +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source