Results 131 to 140 of about 2,189,205 (291)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Influencing Factor Analysis of First-Choice Medical Institutions for Aging People in China. [PDF]
Patient Prefer Adherence, 2023 Xie X, Zhao Z, Wu Q.
europepmc +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Measuring the importance of influencing factor for COVID-19 vaccination intention in China. [PDF]
Front Public Health, 2023 Su Y, Li S, Xue J, Li A, Zhu T.
europepmc +1 more source
Uncertainty of the optimum influence factor levels in multicriteria optimization using the concept of desirability [PDF]
The Desirability Index (DI) is a widely used method for multicriteria optimization in industrial quality control, by which optimal levels of the process influencing factors are determined in order to archieve maximum process quality.
Trautmann, Heike, Weihs, Claus
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Factors influencing the adoption of mobile services consumers' preferences using analytic hierarchy process [PDF]
The rapid and widespread development of innovations in mobile services is changing societies and improving lives around the world. Due to lagging adoption, many of these new innovations have yet failed to generate revenue that was expected by mobile ...
Bouwman, Harry +3 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Assessing Medication Literacy and Its Determinants in Chinese Patients with Multimorbidity
Patient Preference and AdherenceXinyi Li,1,2 Changcheng Shi,2,3 Lihong Liu,1 Yibo Wu4 1Department of Pharmacy, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,
Li X, Shi C, Liu L, Wu Y
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