Results 191 to 200 of about 9,732,873 (283)
Collaboration for Healthy Ageing Through Preventive Home Visits: Identifying Home Visitors' Collaboration Partners. [PDF]
Nivestam A +3 more
europepmc +1 more source
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Individual Influence in Population Pharmacokinetics Depends on Underlying Mechanism: Evidence from a Jackknife ΔOFV Approach. [PDF]
Simon N, von Fabeck K.
europepmc +1 more source
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Global research trends of myopia in children and adolescents: A bibliometric review with hotspot visualization. [PDF]
Yin XL, Ji SX, Li XX.
europepmc +1 more source
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Native and introduced megafauna have convergent effects on animals and ecosystems: a meta-analysis. [PDF]
Lundgren EJ +6 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
DEMATEL-based gamified instructional design for music teacher education. [PDF]
Chen C, Ahmad Rashid RB, Xue L.
europepmc +1 more source

