Results 101 to 110 of about 8,955,500 (341)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. [PDF]

PLoS Pathogens, 2009
Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo.
Margaret A Scull, Laura Gillim-Ross, Celia Santos, Kim L Roberts, Elena Bordonali, Kanta Subbarao, Wendy S Barclay, Raymond J Pickles   +7 more
doaj   +1 more source

Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses [PDF]

, 2012
The pathogenesis of human influenza H5N1 virus infection remains poorly understood and controversial. Cytokine dysregulation in human infection has been hypothesized to contribute to disease severity.
Chan, MCW, Chan, WY, Leung, CYH, Nicholls, JM, Peiris, JSM   +4 more
core   +1 more source

Seasonal Human Influenza: Treatment Options [PDF]

Current Treatment Options in Infectious Diseases, 2014
Seasonal influenza can be a self-limiting illness in healthy individuals but is associated with short-term morbidity and economic burden. Influenza can cause significant morbidity and mortality in young children, the elderly, pregnant and post-partum women, patients with co-morbidities and the immunocompromised.
Pei Yi Ng, Emily K. Rowe, Thiaghu Chandra, Mark I-Cheng Chen, Mark I-Cheng Chen, Yee Sin Leo, Yee Sin Leo   +6 more
openaire   +3 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Vacinação contra o vírus influenza em gestantes: cobertura da vacinação e fatores associados

Einstein (São Paulo)
OBJETIVO: Descrever a cobertura vacinal de gestantes para influenza e fatores associados à recusa ou à aceitação da vacina. MÉTODOS: Estudo descritivo, prospectivo, que incluiu 300 puérperas atendidas no Hospital e Maternidade Santa Joana (SP).
Renato de Ávila Kfouri, Rosana Richtmann   +1 more
doaj   +1 more source

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses [PDF]

, 2018
Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to ...
AC Banyard, AGD Bean, B Hu, CR Gaush, D Bernasconi, D Dlugolenski, DS Poole, EA Govorkova, GS Freidl, I Eckerle, I Ramos, Isabella Eckerle, J Stevens, J Xie, K Shuai, Kin-Chow Chang, M Delgado-Ortega, M Hoffman, M Juozapaitis, O Planz, R Pinto, RK Nelli, RK Nelli, S Matikainen, S Panzer, S Tong, SH Seo, SJ Gamblin, SV Kuchipudi, Tessa Slater, V Sandekian, W Weis, Y Wu   +32 more
core   +3 more sources

Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

Frontiers in Microbiology, 2017
In spite of there being a number of vaccines, influenza remains a significant global cause of morbidity and mortality. Understanding more about natural and vaccine induced immune protection against influenza infection would help to develop better ...
V. Gould, J. Francis, Katie Anderson, B. Georges, A. Cope, J. Tregoning   +5 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

A comparison of clinical and epidemiological characteristics of fatal human infections with H5N1 and human influenza viruses in Thailand, 2004-2006. [PDF]

PLoS ONE, 2011
BACKGROUND: The National Avian Influenza Surveillance (NAIS) system detected human H5N1 cases in Thailand from 2004-2006. Using NAIS data, we identified risk factors for death among H5N1 cases and described differences between H5N1 and human (seasonal ...
Vivek Shinde, Wanna Hanshaoworakul, James M Simmerman, Ubolrat Narueponjirakul, Wiwan Sanasuttipun, Suchada Kaewchana, Darin Areechokechai, Kumnuan Ungchusak, Alicia M Fry   +8 more
doaj   +1 more source