Results 181 to 190 of about 325,943 (270)

Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations. [PDF]

Virol J
Peng X, Wen X, Deng J, Yuan M, Liu Y, Zhou Y, Du X, Yang H, Jiang G, Li X, Yin F, Liu P, Tang Y, Tan Z, Yu Z, Chen S.   +15 more
europepmc   +1 more source

NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin‐Binding Integrins

Advanced Science, EarlyView.
Cells transduce the rigidity of the environment into biochemical cues through mechanotransductive cascades that modulate cell behavior. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer involved in regulating cell behavior via specific crosstalk with fibronectin‐binding integrins.
Juan Gonzalez‐Valdivieso, Giuseppe Ciccone, Udesh Dhawan, Tezz Quon, Eva Barcelona‐Estaje, Aleixandre Rodrigo‐Navarro, Rafael R. Castillo, Graeme Milligan, Patricia Rico, Manuel Salmeron‐Sanchez   +9 more
wiley   +1 more source

Human Cases of Highly Pathogenic Avian Influenza A(H5N1) - California, September-December 2024. [PDF]

MMWR Morb Mortal Wkly Rep
Zhu S, Harriman K, Liu C, Kraushaar V, Hoover C, Shim K, Brummitt SI, Limas J, Garvey K, McNary J, Gao NJ, Ryder R, Stavig B, Schapiro J, Morales C, Wadford DA, Howard H, Heffelfinger J, Campagna R, Iniguez-Stevens E, Gharibi H, Lopez D, Esbenshade L, Ptomey P, Trivedi KK, Herrera JA, Locke J, Moss N, Rzucidlo P, Hernandez K, Nguyen M, Paul S, Mateo J, Del Carmen Luna C, Chang Y, Rangel M, DeLeon K, Masood A, Papasozomenos T, Moua P, Reinhart K, Kniss K, Davis CT, Kirby MK, Pan E, Murray EL, Los Angeles County H5 Response Team, California Department of Public Health H5 Laboratory Response Team.   +47 more
europepmc   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Genetic evolution and molecular characteristics of avian influenza viruses in Jining from 2018 to 2023. [PDF]

Front Microbiol
Zhao M, Dou H, Jiang Y, Jia Y, Yue Y, Li L, Huang S, Si M, Wang J, Jiao B, Wang X.   +10 more
europepmc   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

The intersection of influenza infection and autoimmunity. [PDF]

Front Immunol
Xie S, Wei J, Wang X.
europepmc   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

Advanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park   +15 more
wiley   +1 more source

Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model. [PDF]

Emerg Infect Dis
Sun X, Belser JA, Li ZN, Brock N, Pulit-Penaloza JA, Kieran TJ, Pappas C, Zeng H, Chang JC, Carney PJ, Bradley-Ferrell BL, Stevens J, Tumpey TM, Levine MZ, Maines TR.   +14 more
europepmc   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source