Results 181 to 190 of about 314,289 (259)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination. [PDF]

Hum Vaccin Immunother
Rzymski P, Szczepańska B, Wasielewska Z, Pawłowska M, Cywińska K, Świerczynski J, Dobrzeniecka A, Małecka I, Poniedziałek B, Flisiak R, Zarębska-Michaluk D.   +10 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue. [PDF]

Emerg Infect Dis
Hui KPY, Ho JCW, Ng KC, Webby RJ, Peiris M, Nicholls JM, Chan MCW.   +6 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Post-pandemic resurgence and co-detectiondynamics of respiratory pathogens revealed by syndromic multiplex PCR. [PDF]

BMC Microbiol
Aygar IS.
europepmc   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Circulation of Influenza and Other Respiratory Viruses in Tunisia, 2022-2023 Season. [PDF]

Influenza Other Respir Viruses
Zoubeir B, Hind B, Sonia D, Salma A, Rachel WE, Hakim EG, Rihab Y, Nacef BM, Amal M, Ichrak B, Emna E, Najla BS, El Houda GN, Radhouane T, Leila B, Chokri BH, Takoua M, Mohamed B, Mounir BJ, Khaled M, Jalila BK, Nissaf BA, Afif BS, Dhafer L, Kinda Z, Ilhem BB.   +25 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Next-Generation Sequencing Strategies During the 2024-2025 Avian Influenza A(H5N1) Emergency Response in the U.S. [PDF]

Viruses
Frederick JC, Lacek KA, Wersebe MJ, Shu B, Keong LM, DaSilva J, Wilson MM, Sheffield SR, Liddell J, Burnett N, Chau R, Sullivan AH, Jang Y, De La Cruz JA, Pusch EA, Cui D, Hatta Y, Schatzman S, Hassell N, Zheng XY, Nguyen HT, Gubareva L, Kondor R, Di H, Dugan VG, Davis CT, Rambo-Martin BL, Kirby MK.   +27 more
europepmc   +1 more source