Results 171 to 180 of about 1,005,830 (323)

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

open access: yesAdvanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung   +8 more
wiley   +1 more source

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

open access: yesAdvanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong   +7 more
wiley   +1 more source

Engineering Highly Cellularized Living Materials via Mechanical Agitation

open access: yesAdvanced Functional Materials, EarlyView.
A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani   +9 more
wiley   +1 more source

Development of Substrate‐Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross‐Linked Hydrogel Coatings for Biomedical Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
A new antifouling, antithrombogenic, and bactericidal hydrogel coating method is developed for implantable medical devices. The hydrogel coating can be easily formed by visible‐light crosslinking and is universally applicable to all substrates, ranging from polymers to metals.
Soonjong Roh   +4 more
wiley   +1 more source

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

open access: yesNature Communications
Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- and post-
Feng Liu   +18 more
doaj   +1 more source

Fluid Shear‐Controlled Pro/Anti‐Inflammatory Osteomodulatory Construct for Drug‐Free Immune Activation Through Cationic Ion Channel Activation

open access: yesAdvanced Healthcare Materials, EarlyView.
A 3D‐printed PCL scaffold coated with Arginine was laminated with electrospun polyvinyl alcohol (PVA) nanofibers containing cationic cellulose nanocrystals (PVA@cCNC). This created nanoisland‐like regions of aligned and random cCNC‐rich fibers. The composite scaffold, under fluid shear stimulation, modulated macrophage polarization from M1 to M2 ...
Keya Ganguly   +8 more
wiley   +1 more source

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