Results 91 to 100 of about 24,579,249 (345)

Influenza A Virus Subtyping: Paradigm Shift in Influenza Diagnosis [PDF]

Journal of Clinical Microbiology, 2009
Seasonal influenza causes substantial mortality and morbidity in the United States, with approximately 365,000 hospitalizations and 50,000 deaths per year ([8][1], [9][2]). Multiple influenza virus types and subtypes cause human infection, and currently circulating subtypes of influenza A ...
Michael, Vinikoor, Jane, Stevens, John, Nawrocki, Kamaljit, Singh   +3 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Nature Communications
Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- and post-
Feng Liu, F. Liaini Gross, Sneha Joshi, Manjusha Gaglani, Allison L. Naleway, Kempapura Murthy, Holly C. Groom, Meredith G. Wesley, Laura J. Edwards, Lauren Grant, Sara S. Kim, Suryaprakash Sambhara, Shivaprakash Gangappa, Terrence Tumpey, Mark G. Thompson, Alicia M. Fry, Brendan Flannery, Fatimah S. Dawood, Min Z. Levine   +18 more
doaj   +1 more source

A case report of myocarditis masquerading as hypertrophic cardiomyopathy

Annals of Pediatric Cardiology, 2020
We report the case of a 16-year-old girl diagnosed with myocarditis, although initial echocardiographic imaging was consistent with hypertrophic cardiomyopathy (HCM). The diagnosis of myocarditis was made with the findings of troponin elevation, presence
Jaclyn R Giafaglione, Adam K Morrison, Deipanjan Nandi   +2 more
doaj   +1 more source

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

Cell, 2016
Summary Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852 ...
N. Kallewaard, D. Corti, P. Collins, U. Neu, Josephine M. McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, F. Palmer-Hill, A. Q. Yuan, P. Walker, M. K. Vorlaender, S. Bianchi, B. Guarino, A. De Marco, Fabrizia Vanzetta, Gloria Agatic, Mathilde Foglierini, Debora Pinna, B. Fernandez-Rodriguez, Alexander Fruehwirth, Chiara Silacci, R. Ogrodowicz, S. Martin, F. Sallusto, J. Suzich, A. Lanzavecchia, Qing Zhu, S. Gamblin, J. Skehel   +28 more
semanticscholar   +1 more source

Modeling Influenza Virus Infection: A Roadmap for Influenza Research [PDF]

Viruses, 2015
Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus pneumoniae, are one of the main complications and responsible for the enhanced morbidity and mortality associated with IAV infections. In spite of the significant advances in
Boianelli, Alessandro, Nguyen, Van Kinh, Ebensen, Thomas, Schulze, Kai, Wilk, Esther, Sharma, Niharika, Stegemann-Koniszewski, Sabine, Bruder, Dunja, Toapanta, Franklin R, Guzmán, Carlos A, Meyer-Hermann, Michael, Hernandez-Vargas, Esteban Abelardo   +11 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Immunogenicity and effectiveness of a bivalent influenza A/H1N2 vaccine strain against seasonal human influenza A viruses in mice

Journal of Genetic Engineering and Biotechnology, 2022
Background Recent studies and reports have documented the ability of the co-circulating seasonal influenza A/H1N1 (ancestor: 2009 pandemic H1N1) and A/H3N2 to exchange their genetic segments, generating a novel H1N2 strain in different geographical ...
Mina Nabil Kamel, Sara H. Mahmoud, Yassmin Moatasim, Ahmed El Taweel, Mahmoud Shehata, Mohamed Refaat Shehata, Elsayed Tarek AbdElSalam, Mohamed A. Ali, Ahmed Mostafa   +8 more
doaj   +1 more source

Vaccine Epidemiology and Decision-Making: A Bryant Student Focus [PDF]

, 2018
The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1).
Coburn, Hannah
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source