Results 31 to 40 of about 384,522 (254)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Shui Fu,1 Miao-Miao Zhang,2 Liang Zhang,1 Li-Feng Wu,1 Qi-Lei Hu1 1Department of Clinical Laboratory, The First People’s Hospital of Yuhang District, Hangzhou, Zhejiang, 311100, People’s Republic of China; 2Department of Emergency, The Fifth People’s ...
Fu S, Zhang MM, Zhang L, Wu LF, Hu QL
doaj
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined markedly in 2020-21 after SARS-CoV-2 emerged but increased in 2021-22.
Uyeki, Timothy M +4 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Generating cross-reactive vaccines aimed at targeting all human influenza A virus subtypes is among high priority tasks in contemporary vaccinology.
L. M. Tsybalova +6 more
doaj +1 more source
Clinical Usage of Influenza Rapid Test During Influenza Season
INTRODUCTION: Objective: Influenza A and B are important viral pathogens causing respiratory infection epidemics potentially with high morbidity and mortality.Herein we aimed to investigate clinical usage of influenza rapid test in clinical practice ...
Kamile Ötiken Arıkan
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Type A h1n1 influenza got its start in 2009 during a pandemic that swept across many countries and contributed to massive mortality. It was characterised by its prevalence among young adults and children.
Kacper Lee +9 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source

