Results 61 to 70 of about 837,589 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination [PDF]

, 2013
Influenza vaccination has been implicated in Guillain Barré Syndrome (GBS) although the evidence for this link is controversial. A case–control study was conducted between October 2010 and May 2011 in seven Italian Regions to explore the relation between
Beghi, E, Benedetti, M D, Chiò, A, D'Alessandro, R, Filippini, G, Galeotti, F, Granieri, E, Itang, study group., Logroscino, G, Massari, M, Pugliatti, M, Raschetti, R, Santuccio, C   +12 more
core   +1 more source

[Influenza A pneumonia].

Nederlands tijdschrift voor geneeskunde, 2000
The majority of influenza cases are not associated with complications. Secondary bacterial pneumonia, commonly caused by Streptococcus pneumoniae or Staphylococcus aureus, is well known to most clinicians. Primary influenza viral pneumonia, characterized by rapidly progressive hypoxia and respiratory insufficiency together with non-consolidating ...
Veenstra, R P, Boelen, C C, Zijlstra, J G, Bos, A P, Ligtenberg, J J   +4 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Serologic evidence of seasonal influenza A and B in HIV patients on combined antiretroviral therapy in Lagos, Nigeria

African Journal of Laboratory Medicine, 2020
Background: Influenza and HIV are endemic in Nigeria but there is no epidemiological data on the co-infection of influenza A and B among HIV patients. Objective: We investigated seasonal influenza A and B, and co-infection among HIV patients on combined
AbdulAzeez A. Anjorin, Barakat A. Adepoju   +1 more
doaj   +1 more source

Influenza vaccination uptake among people aged over 85 years: an audit of primary care practice in the UK [PDF]

, 2014
Public health research and national guidelines have advocated for seasonal influenza vaccination in the elderly. General practice has established itself as an ideal setting for the safe administration and monitoring of vaccines.1 Due to waning immune
Arnott, ND, Fitchett, JR
core   +2 more sources

Influenza A Virus Subtyping: Paradigm Shift in Influenza Diagnosis [PDF]

Journal of Clinical Microbiology, 2009
Seasonal influenza causes substantial mortality and morbidity in the United States, with approximately 365,000 hospitalizations and 50,000 deaths per year ([8][1], [9][2]). Multiple influenza virus types and subtypes cause human infection, and currently circulating subtypes of influenza A ...
Michael, Vinikoor, Jane, Stevens, John, Nawrocki, Kamaljit, Singh   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Nature Communications
Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- and post-
Feng Liu, F. Liaini Gross, Sneha Joshi, Manjusha Gaglani, Allison L. Naleway, Kempapura Murthy, Holly C. Groom, Meredith G. Wesley, Laura J. Edwards, Lauren Grant, Sara S. Kim, Suryaprakash Sambhara, Shivaprakash Gangappa, Terrence Tumpey, Mark G. Thompson, Alicia M. Fry, Brendan Flannery, Fatimah S. Dawood, Min Z. Levine   +18 more
doaj   +1 more source

A case report of myocarditis masquerading as hypertrophic cardiomyopathy

Annals of Pediatric Cardiology, 2020
We report the case of a 16-year-old girl diagnosed with myocarditis, although initial echocardiographic imaging was consistent with hypertrophic cardiomyopathy (HCM). The diagnosis of myocarditis was made with the findings of troponin elevation, presence
Jaclyn R Giafaglione, Adam K Morrison, Deipanjan Nandi   +2 more
doaj   +1 more source