Results 331 to 340 of about 945,008 (390)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

The interaction of RNA G-quadruplexes from the influenza A virus vRNA with TMPyP4 and BRACO-19 ligands. [PDF]

PLoS One
Nalewaj M, Sliwiak J, Zielinska K, Zmora P, Niedziałek D, Wieczorek G, Kierzek E, Szabat M.   +7 more
europepmc   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Microtubule detyrosination links inflammasome activation to apoptotic cell death in macrophages upon influenza A virus infection. [PDF]

J Virol
Kar J, Hirohama M, Nakayama K, Lee S, Kawaguchi A.   +4 more
europepmc   +1 more source

Plant-Derived Carotenoid Lutein Demonstrates Multifunctional Antiviral Activity against Influenza A Virus <i>in vitro</i>. [PDF]

J Microbiol Biotechnol
Kim JW, Ryu HS, Lee S, Jeon S, Yoon SW, Jang YH.   +5 more
europepmc   +1 more source

Nanchangmycin suppresses influenza A virus infection by blocking endosomal acidification. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Zhang H, Liu C, Cai S, Wu Y, Shang L, Yang F, Liu J, Wei N, Liu Y, Wang M, Gao F, Liu Q, Chen H, Tong G, Chen Y, Gu F.   +15 more
europepmc   +1 more source

The role of long non-coding RNAs and circular RNAs in immune evasion of influenza A virus: recent advances. [PDF]

Front Cell Infect Microbiol
Ju Y, Li Y, Zhou C, Yu X.
europepmc   +1 more source

Correction: Innate immune role of IL-6 in influenza a virus pathogenesis. [PDF]

Front Cell Infect Microbiol
Li X, Huang C, Rai KR, Xu Q.
europepmc   +1 more source

Hypoxia-inducible factor-1α exacerbates immune injury induced by influenza A virus and Streptococcus pneumoniae coinfection. [PDF]

BMC Infect Dis
Wei Y, Zhao Z, Wang T, Tang Z, Yang H, Tao C.   +5 more
europepmc   +1 more source