Results 51 to 60 of about 13,577,953 (257)

Circulation of influenza A and B in the Czech Republic from 2000-2001 to 2015-2016

BMC Infectious Diseases, 2019
Background To improve national influenza vaccination recommendations, additional data on influenza A and B virus circulation are needed. Here, we describe the circulation of influenza A and B in the Czech Republic during 16 seasons.
Martina Havlickova, Sophie Druelles, Helena Jirincova, Radomira Limberkova, Alexander Nagy, Anvar Rasuli, Jan Kyncl   +6 more
doaj   +1 more source

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons

Brazilian Journal of Infectious Diseases, 2020
Introduction: Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than ...
Clarisse M. Machado, Ana Carolina Mamana Fernandes de Souza, Camila Malta Romano, Wilton dos Santos Freire, Ângela Aparecida Costa, Walter Manso Figueiredo, Cláudio S. Pannuti, Expedito J.A. Luna   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.

PLoS ONE, 2013
IntroductionThe 2011-12 trivalent influenza vaccine contains a strain of influenza B/Victoria-lineage viruses. Despite free provision of influenza vaccine among target populations, an epidemic predominated by influenza B/Yamagata-lineage viruses occurred
Yi-Chun Lo, Jen-Hsiang Chuang, Hung-Wei Kuo, Wan-Ting Huang, Yu-Fen Hsu, Ming-Tsan Liu, Chang-Hsun Chen, Hui-Hsun Huang, Chi-Hsi Chang, Jih-Haw Chou, Feng-Yee Chang, Tzou-Yien Lin, Wen-Ta Chiu   +12 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Clinical similarities between influenza A and B in children: a single-center study, 2017/18 season, Korea

BMC Pediatrics, 2019
Background The global burden of seasonal influenza on medical care has been one of the greatest in the pediatric population. The attention drawn to influenza B was relatively low compared to influenza A, probably because the influenza B virus was thought
Yu Na Oh, San Kim, Young Bae Choi, Sung Il Woo, Youn-Soo Hahn, Joon Kee Lee   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

PLoS ONE, 2019
We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study.
Saverio Caini, Gabriela Kusznierz, Verònica Vera Garate, Sonam Wangchuk, Binay Thapa, Francisco José de Paula Júnior, Walquiria Aparecida Ferreira de Almeida, Richard Njouom, Rodrigo A Fasce, Patricia Bustos, Luzhao Feng, Zhibin Peng, Jenny Lara Araya, Alfredo Bruno, Doménica de Mora, Mónica Jeannette Barahona de Gámez, Richard Pebody, Maria Zambon, Rocio Higueros, Rudevelinda Rivera, Herman Kosasih, Maria Rita Castrucci, Antonino Bella, Hervé A Kadjo, Coulibaly Daouda, Ainash Makusheva, Olga Bessonova, Sandra S Chaves, Gideon O Emukule, Jean-Michel Heraud, Norosoa H Razanajatovo, Amal Barakat, Fatima El Falaki, Adam Meijer, Gé A Donker, Q Sue Huang, Tim Wood, Angel Balmaseda, Rakhee Palekar, Brechla Moreno Arévalo, Ana Paula Rodrigues, Raquel Guiomar, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Florette Treurnicht, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Mai T Q Le, Phuong V M Hoang, Clotilde El Guerche-Séblain, John Paget, Global Influenza B Study team   +54 more
doaj   +1 more source

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Brazilian Journal of Infectious Diseases, 2016
Data on the burden of disease and circulation patterns of influenza B lineages for Brazil are limited. This review aims to describe the pattern of influenza B occurrence in Brazil to have a better understanding of its epidemiology and its relevance when ...
Eliana Nogueira Castro de Barros, Otavio Cintra, Erika Rossetto, Laís Freitas, Romulo Colindres   +4 more
doaj   +1 more source