Results 151 to 160 of about 14,686,195 (254)

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Development and Qualification of a Pseudotyped Virus-Based Microneutralisation Assay for Influenza D Virus. [PDF]

Influenza Other Respir Viruses
Marotta MG, Mapulanga T, Maina M, Daly J, Camero M, Diemen PM, Everett HE, Montomoli E, da Costa K, Temperton N, Trombetta CM.   +10 more
europepmc   +1 more source

Influenza D Virus: A Review and Update of Its Role in Bovine Respiratory Syndrome. [PDF]

Viruses, 2022
Ruiz M, Puig A, Bassols M, Fraile L, Armengol R.   +4 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

First detection and molecular characterization of influenza D virus in livestock from Kazakhstan reveals circulation of the D/Yama2019 lineage. [PDF]

Front Vet Sci
Kassymbekov Y, Sabyrzhan T, Nuralibekov S, Shayakhmet Y, Suleimenova S, Khan Y, Kumar M, Karamendin K, Kydyrmanov A.   +8 more
europepmc   +1 more source

Characterization of Influenza D Virus in Danish Calves. [PDF]

Viruses, 2022
Goecke NB, Liang Y, Otten ND, Hjulsager CK, Larsen LE.   +4 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Efficient replication of influenza D virus in the human airway underscores zoonotic potential. [PDF]

Proc Natl Acad Sci U S A
Sanders CG, Liu M, Fusco JA, Ohl EM, Tarbuck NN, King EM, Huey D, Fabrizio TP, Chen P, Panfil AR, Webby RJ, Peeples ME, Bowman AS, Warren CJ.   +13 more
europepmc   +1 more source

Influenza D virus exposure among US cattle workers: A call for surveillance. [PDF]

Zoonoses Public Health, 2023
Leibler JH, Abdelgadir A, Seidel J, White RF, Johnson WE, Reynolds SJ, Gray GC, Schaeffer JW.   +7 more
europepmc   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source