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The benefits of prototypes: The case of medical concepts [PDF]
, 2017 In the present paper, we shall discuss the notion of prototype and show its benefits. First, we shall argue that the prototypes of common-sense concepts are necessary for making prompt and reliable categorisations and inferences.Amoretti, Cristina, Frixione, Marcello, Lieto, Antonio +2 morecore Modularity Enhances the Rate of Evolution in a Rugged Fitness Landscape
, 2015 Biological systems are modular, and this modularity affects the evolution of
biological systems over time and in different environments. We here develop a
theory for the dynamics of evolution in a rugged, modular fitness landscape.Chen, Man, Deem, Michael W., Park, Jeong-Man, Wang, Dong +3 morecore +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman +206 morewiley +1 more sourceVacinação contra influenza e pneumococo na insuficiência cardíaca: uma recomendação pouco aplicada Vacunación contra influenza y neumococo en la insuficiencia cardíaca: una recomendación poco aplicada Influenza and pneumococcal vaccination in heart failure: a little applied recommendation
Arquivos Brasileiros de Cardiologia, 2011 FUNDAMENTO: A insuficiência cardíaca (IC) cursa com frequentes descompensações e admissões ao serviço de emergência. Vacinação contra Influenza (INF) e Pneumococo (PNM) são recomendadas nas diretrizes, entretanto, as infecções respiratórias são a ...Wolney de Andrade Martins, Margarete Domingues Ribeiro, Lucia Brandão de Oliveira, Luciana da Silva Nogueira de Barros, Ana Cristina da Silva Moreira Jorge, Camila Mirante dos Santos, Daniella de Paiva Almeida, Isaías Fiuza Cabral, Renata Tavares de Souza, Thyago Antônio Biagioni Furquim +9 moredoaj Transition From a High‐Sugar and Butter to a Standard Diet Leads to Cecal Dysbiosis, Disrupts Intestinal Homeostasis, and Favors Increased Ethanol Consumption and Preference
The FASEB Journal, Volume 39, Issue 19, 15 October 2025.Male C57BL/6 mice were switched from a high‐sugar/high‐fat diet to a control diet with or without free‐choice 10% ethanol. The switch reshaped the cecal microbiota and metabolome (alpha diversity increased; polyamines and selected bile acids decreased) and reduced colonic barrier markers.Renato Elias Moreira Júnior, Mírian Velten Mendes, Mariana Siqueira Amormino, Gwenaëlle Randuineau, Célia Le Boulenger, Sylvie Guérin, Véronique Romé, Gaelle Boudry, Ana Lúcia Brunialti‐Godard +8 morewiley +1 more sourceLa nueva influenza A/H1N1
Acta Médica Peruana, 2009
En el volumen 23 (1) 2006 de nuestra revista Acta Médica Peruana, los Drs. Fernando Osores, César Cabezas, Jorge Gómez y el suscrito publicamos un importante artículo científico de revisión: Influenza humana y aviar: amenaza de una pandemia humana y ...Ciro Cirodoaj Influenza em animais heterotérmicos Influenza in heterothermics
Revista da Sociedade Brasileira de Medicina Tropical, 2004 O objetivo foi pesquisar Ortomyxovirus em animais heterotérmicos. Coletou-se sangue de serpentes dos gêneros Bothrops e Crotalus e de sapo e rãs dos gêneros Bufo e Rana, para a detecção dos receptores de hemácias e anticorpos específicos, ao vírus ...Dalva Assunção Portari Mancini, Rita Maria Zucatelli Mendonça, Aurora Marques Cianciarullo, Leonardo Setsuo Kobashi, Hermínio Gomes Trindade, Wilson Fernandes, José Ricardo Pinto +6 moredoaj +1 more sourceVírus influenza
Clinical and Biomedical Research, 2013 Um dos registros mais antigos da gripe descrita como doença é de autoria de Hipócrates, em meados do ano 412 a.C. Desta forma, seu agente etiológico, o vírus influenza, tem circulação entre a população humana há muito tempo.Fernanda de-Parisdoaj +2 more sources